4 Serotonin Supplements to Treat Depression, Anxiety, and Insomnia Yourself

Feeling pessimistic, sad, panicky, or irritable? Can’t sleep? Here's how to use four powerful, research-proven serotonin supplements to restore serotonin deficiency and the calm, positive mood you desire.

serotonin supplements

A number of supplements have now been shown to increase serotonin and effectively treat symptoms of serotonin deficiency.

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Research shows that when you’re consistently sad, pessimistic, or moody you may have a serotonin deficiency that you can treat yourself by using serotonin supplements. The 4 natural supplements presented here have all been shown to help treat serotonin deficiency symptoms such as depression, insomnia, and more by increasing serotonin levels naturally.

What Is Serotonin?

Serotonin, the “happy neurotransmitter,” is a powerful brain chemical intricately linked with mental health. Sufficient serotonin in the brain allows you to feel calm and optimistic and provides a sense of well-being, while serotonin deficiency has the opposite effect. Low serotonin levels (or abnormal serotonin function) is the most recognized underlying cause of depression. Studies show that serotonin imbalances may not only lead to classic depression symptoms like sadness and pessimism, but other symptoms such as food cravings, sleep disturbances, aggression, panic, obsessiveness, and more. 


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Increasing Serotonin with Supplements

The good news is that a number of supplements have been shown to increase serotonin and effectively treat symptoms of serotonin deficiency. SAM-e, 5-HTP, and L-tryptophan St. John’s Wort have each been shown in multiple human studies to affect serotonin imbalances and to treat depression. Let’s take a brief look at how to use each of these supplements to boost mood, treat insomnia, and ease other low serotonin symptoms.

5-HTP.  Your body makes 5-hydroxy tryptophan, or 5-HTP, from tryptophan, and then converts it into serotonin. When taken as a supplement, 5-HTP is well-absorbed and crosses the blood-brain barrier where it gets converted to serotonin. 5-HTP is believed to offer stronger serotonin support than L-tryptophan (see below). Clinical trials have confirmed the efficacy of 5-HTP supplements for depression, sleep disorders, binge eating and panic disorders.[1-3]

L-Tryptophan. L-Tryptophan is an essential amino acid required by the body to synthesize serotonin. As discussed above, the conversion of L-tryptophan to serotonin is a two-step process in which 5-HTP is synthesized as an intermediate step. Taking L-tryptophan as a supplement enhances the synthesis of serotonin and increases serotonin levels within the body.[4] Nevertheless, integrative practitioners report success with the use of L-tryptophan for insomnia, mild depression, and for people who do not tolerate 5-HTP since, compared to 5-HTP, L-tryptophan is generally considered more gentle. It has even been found to help non-depressed, healthy people process emotions in a more positive way.[5]

SAM-e. S-adenosyl methionine (SAM-e—pronounced Sammy), produced from the amino acid methionine, is present in all the body’s cells and is required for hundreds of reactions, including the synthesis of serotonin. As a supplement, SAM-e has been used extensively for treating depression in Europe for over 30 years, and a review of SAM-e studies published in the American Journal of Clinical Nutrition concluded that SAM-e supplementation was a safe and effective treatment for depression.[6] Drs. Richard Brown, M.D., of Columbia University and George Papakostas, M.D., of Harvard Medical School both advocate the use of SAM-e for clinical depression.[7,8]

Saint John’s Wort. Extracts of the flowering St. John’s wort plant exert their antidepressant actions by inhibiting the reuptake of serotonin as well as norepinephrine and dopamine, making more of these neurotransmitters available to the brain. For people suffering from mild to moderate depression, studies show that St. John’s wort extracts are significantly more effective than placebo.[9] They have been found to be better tolerated but to work just as well as standard antidepressant drugs.[9]

Safety First

Though having too little serotonin is not good for you, too much serotonin can cause harm. Do not take more than one serotonin boosting supplement at a time. Serotonin supplements may not be appropriate for all types of depression and may not be compatible with certain types of depression medication. If you are taking an anti-depressant, consultation with a healthcare practitioner is strongly advised.

Other Natural Remedies for Mood Enhancement

Depression, anxiety, and other mood disorders have other possible underlying causes in addition to serotonin deficiency. For example, read Could Your Depression Be Caused by a Sleep Disorder? Depression Can Be One of the Many Surprising Sleep Apnea Symptoms.

The neurotransmitter dopamine is also involved in mental-emotional health, and specific dopamine supplements may also be indicated. Learning more about all the potential underlying causes of depression and anxiety can help you target your natural treatment protocol.

[1] Asian J Psychiatr. 2013 Feb;6(1):29-34.

[2] Eat Weight Disord. 2012 Mar;17(1):e22-8.

[3] Altern Med Rev. 1998 Aug;3(4):271-80.

[4] Anal Bioanal Chem. 2012 Feb;402(4):1593-600.

[5] Psychopharmacology (Berl). 2006 Jul;187(1):121-30.

[6] Am J Clin Nutr. 2002 Nov;76(5):1158S-61S.

[7] 141st APHA Annual Meeting. Abstract 283939. To be presented Nov 6, 2013.

[8] Can J Psychiatry. 2012 Jul;57(7):406-13.

[9] J Clin Psychiatry. 2009;70 Suppl 5:23-7.

Originally published in 2013 and updated.

  • I’ve used one of these serotonin supplements myself. 5-HTP helps ease my stress levels and I get a restful night’s sleep. It works great!

  • Lydia E.

    After carefully getting off of celexa and bupropion which I had been on for many years to the effect that I never wanted to go out or do anything, I replaced them several months ago with 200 mg 5 htp. I am amazed at the total difference this has made in my life. I feel like I have gone back 20 years and reclaimed my life. My only regret is that I did not do this long ago.

  • Greg H.

    As this article aptly points out, “too much serotonin can cause harm.” An excess can cause what is called “serotonin syndrome,” the effects of which are ironically often similar to not having enough of it.

    Apparently the combination of my very nutrient-rich diet and just my basic personal physiology (I don’t take any medications at all) produces all the serotonin I need so even a slight increase in my serotonin level pushes me over the line into having too much. As an experiment I tried one 50 mg dose of 5-HTP at bedtime once, and had what I’m sure was the worst night’s sleep in my life, with my mind just spinning and spinning which is something it never, ever does naturally. So please, do take the advice wisely given here and be careful about starting with a very low dose to see how it affects you. “Your mileage may vary.”

  • Jennifer S.

    My husband has had positive results after using SAMe. It took about three to four weeks to notice a difference.

  • Can this cure my crippling depression? I want to be dead.

  • depends on the type of depression, try curcumin, its really powerful and safe. instead of 5HTP(which can decrease other neurotransmitters over time), try L-Tryptophan and L-Tyrosine may help you since boots the levels of noradrenaline(norepinefrine) wich helps to cope with mental stress and Vitamin B12

    Personally I have had awesome results with:
    – Turmeric wich its the same as Curcumin but milder(it is known to be safe since its a type of food)
    – Vitamin B12(I advise you to Research first on this one)
    – L-Tyrosine(I advise you to Research first on this one)
    – Omega 3,6,9(I advise you to Research first on this one)

    I was able to stop taking psych meds completely with in a couple of months thanks to these, now I’m very happy living my life better than before

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