Dopamine Supplements to Improve Depression Symptoms, Mood, and Motivation

Dopamine supplements can correct a dopamine deficiency.

dopamine supplements

Any of the four different dopamine supplements discussed in our story (L-Tyrosine, Rhodiola, Mucuna, and L-theanine) may boost the mood of a person with low dopamine levels.


A dopamine deficiency can be effectively treated by using a number of dopamine supplements. A study published in JAMA Psychiatry in the year 2000 reported that people with clinical depression have significantly lower brain levels of the neurotransmitter dopamine.[1] Since then, we’ve learned a lot about dopamine’s role in mood and mental health and about the role of dopamine supplements in restoring low dopamine levels.

When we think about depression, lack of motivation, or difficulty focusing and concentrating, the well-known brain chemical (neurotransmitter) serotonin often comes to mind. While it’s true that serotonin deficiency is a problem for many people with depression and other mental health issues, researchers have known for years that other neurotransmitters such as dopamine are also involved.

Loss of pleasure, loss of motivation, and not having enough focus or concentration to get things done can all be dopamine deficiency symptoms, as can the characteristic “slowness” of many people with depression.

While most pharmaceutical drugs designed to increase dopamine are associated with significant and serious adverse effects, scientists have discovered and clinically tested a number of natural dopamine supplements that can safely increase dopamine levels within the brain and are generally without side effects. Natural and integrative physicians have been successfully using these ingredients to help patients with depression, anxiety, low motivation, and other low dopamine symptoms.

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What Is Dopamine and What Are Dopamine Supplements?

Dopamine normally gets triggered when you approach and expect a reward. With the dopamine drug released in your brain, comes a good feeling and a surge of energy so you can reach your reward. Dopamine motivates you to seek, alerts your attention to things that meet your needs, and motivates you to persist in your pursuit of those things that meet your needs.

Your brain rewards you with dopamine each time you take steps towards a new goal. Without enough dopamine, your motivation goes kaput and you’re unable to experience pleasure from activities usually found enjoyable, e.g. exercise, hobbies, music, sexual activities or social interactions. In other words, dopamine deficiency causes a bad case of the “blahs.”

The four dopamine supplements presented here—L-Tyrosine, Rhodiola, Mucuna, and L-theanine—have each been found in studies to increase dopamine and/or help balance dopamine function in the brain. They can be used as natural dopamine boosters to improve and enhance mood and motivation and to treat dopamine deficiency symptoms like depression, fatigue, lack of interest in life, poor memory, and impulsive behaviors. Read more about these four dopamine supplements below.

1. L-Tyrosine – Dopamine Booster

The conditionally essential amino acid tyrosine is a precursor of catecholamine neurotransmitters, including dopamine. It can be taken through the diet (especially from meat, eggs, and fish) or synthesized in the body. Tyrosine forms DOPA, which is then converted to dopamine, and this, in turn, forms norepinephrine, another neurotransmitter related to mood.

By supporting production of neurotransmitters like dopamine, L-tyrosine supplements can enhance mood, sleep, emotional well-being, and cognitive/mental function, especially under situations involving environmental and emotional stress or when dopamine levels require additional support (some people are genetically programmed to make too little dopamine).[2-4] Start by taking one 500 mg capsule of L-tyrosine. If you feel no benefits within 30 minutes, take a second capsule, and a third in another 30 minutes if you still feel nothing. Continue by taking one to three 500 mg capsules two or three times a day: early morning, mid-morning, and mid-afternoon. Decrease the dose if you feel agitated or your blood pressure increases.

2. Mucuna, L-Dopa Supplements

Mucuna pruriens, commonly known as velvet bean, naturally contains up to 5 percent L-Dopa (levodopa). L-DOPA supplement is the same biochemical that is made in humans from the amino acid L-tyrosine and is then synthesized into dopamine. When taken as a supplement, the L-DOPA from Mucuna can cross the blood-brain barrier to elevate brain dopamine levels.

Powdered mucuna seeds have long been used in Indian traditional medicine as support in the treatment of various illnesses, including Parkinson’s. Recently, studies utilizing Mucuna supplements have shown promising results not just for Parkinson’s but for other conditions related to dopamine deficiency, including depression and psychological stress.[5-7] Mucuna extract has been shown to increase not only dopamine concentrations, but also other neurotransmitters that affect mood, such as serotonin and norepinephrine.[8] Look for an extract of Mucuna pruriens standardized to contain 15% L-DOPA. Take 300 mg twice a day.

3. L-theanine

L-theanine is an amino acid uniquely found in green tea that creates an alert state of relaxation without drowsiness. L-theanine is known to be able to cross the blood-brain barrier and increase dopamine levels in the brain. Animal studies show that L-theanine also increases brain serotonin and GABA. It has anti-depressant and anti-anxiety effects, reduces mental and physical stress, and leads to improvements in learning and memory in humans and animals.[9,10] Even just a single, small dose of L-theanine (100 mg) significantly improves the ability to pay attention and maintain focus compared to placebo.[11] Take 200 mg of L-theanine two to three times daily.

4. Rhodiola

Rhodiola rosea, or “golden root,” is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms resulting from intense physical and psychological stress. Rhodiola exerts its benefits via multiple effects on the central nervous system, including enhancing the stability of dopamine and supporting its reuptake. This leads to notable decreases in depression, anxiety, and fatigue, as well as an increased ability to handle stress.[12]

In human studies, rhodiola has been shown to significantly reduce depression, anxiety, and stress-related fatigue compared to placebo.[13-15] Look for a rhodiola extract derived from Rhodiola rosea root and standardized to contain 3% total rosavins and a minimum 1% salidrosides. Take 170 mg twice a day.

Don’t Forget Multivitamins for Natural Mood Enhancers

Certain mood boosting vitamins, especially zinc, vitamin B6, and folate, are necessary for dopamine synthesis and neurotransmission. These nutrients are often depleted in individuals due to medications, inadequate diets, excessive stress, and toxic environmental exposures, compromising the ability to properly synthesize neurotransmitters like dopamine.

High-potency, high-quality multivitamin/mineral supplements can be natural mood enhancers. They can help replenish these co-factors, enhancing neurotransmitter function and playing a complementary role in supporting emotional wellness.

Potential Side Effects, Precautions, and Drug Interactions with Mood Boosters

Of course, too much dopamine is dangerous and needs to be avoided. Do not take more than one dopamine supplement at a time without first consulting with a healthcare practitioner, preferable one trained in integrative or natural medicine.

Similarly, do not use these dopamine supplements if you are taking methyldopa, antidepressants, or antipsychotic drugs without first consulting with a physician. Tyrosine and Mucuna pruriens may also interact with some nutritional supplements, including St. John’s Wort, 5-HTP, Tryptophan, and SAMe. Therefore, you should also consult your healthcare practitioner before combining these supplements. Do not take these supplements if you are a pregnant or lactating woman.

Additional Ways to Increase Dopamine

In addition to taking dopamine supplements, there are also other ways to naturally increase dopamine. For instance, do you know which foods are natural dopamine boosters and which foods can deplete dopamine?  Working towards a goal can also increase dopamine. By repeating small steps to reach a goal, you can re-wire the dopamine pathways in your brain, ultimately teaching your brain to give you a dopamine surge every time you take that small step. You can also increase dopamine by developing an active, regular, stress reduction practice.[16]

Also, be sure to read about serotonin deficiency and serotonin supplements.

[1] Arch Gen Psychiatry. 2000 Aug;57(8):787-93.

[2] Biol Psychiatry. 2005 May 1;57(9):999-1003.

[3] C R Acad Sci III. 1988;306(3):93-8.

[4] Altern Med Rev. 2009 Jun;14(2):114-40.

[5] Evid Bas Comp Alt Med. 2010;7(1):137-144.

[6] Inventi Impact Ethnopharm. 2013;797.

[7] Pharm online. 2010;1:537-551.

[8] Orient Pharm Exp Med. 2013 Jun;13(2):143-148.

[9] Phytother Res. 2011 Nov;25(11):1636-9.

[10] Nutr Neurosci. 2013 Jul 23.

[11] Neuropharmacology. 2012 Jun;62(7):2320-7.

[12] Phytother Res. 2007 Jan;21(1):37-43.

[13] Nord J Psychiatry. 2007;61(5):343-8.

[14] Altern Complement Med. 2008 Mar;14(2):175-80.

[15] Planta Med. 2009 Feb;75(2):105-12.

[16] Neurosci Lett. 2010 Jul 26;479(2):138-42.

This post was originally published in 2013 and has been updated.

  • Taking these supplements can also help decrease cravings for sugar or alcohol. That’s because low dopamine levels cause cravings, and sugar gives the false sense of “satisfying” that deficiency. Unfortunately, eating sugar or drinking alcohol will only further deplete dopamine levels in the brain. Thus, whether initiated by alcohol or sugar, the compulsive behavior addiction is the same – an undeniable desire for dopamine. So, taking these dopamine supplements will help fight this addictive dopamine depletion-sugar craving cycle!

  • Sorry I av low motivation rhodiola has no positive effects on me -it actually makes me tired and irritable etc. tyrosine has had a minimal effect in some ways but not with motivation. I will try the others.
    Sam Webster

  • Forrest V.

    I Would like to Order these Meds to help me recover from a Back Injury and pain Meds. We’re do I get the Meds from ?
    Thank you

  • One study done on twins didn’t really find much differences between the twins, even if one smoked.

  • Shannon

    Can you take these all at the same time? Or do you take one and see how it works?

  • Angel B.

    I have always been given Serotonin pills, but after 11 years I think I am dopamine deficient. What should I take?

  • Angel and any one else who is interested check out Vitamin D 3 supplements. It helps a whole bunch of these symptoms.

  • Barbara D.

    I have learned that low dopamine levels can also effect a person’s eating patterns; if a person has a low dopamine level, they are never satisfied and always hungry. Have you heard of this before?

  • I want to know what to buy. CAn rhodiola work on its own

  • Joseph P.

    This article is as frustrating as the free guideline: lots of supplements, etc, each one recommended, but no guidance other than dosage. Does one try one after another in search of help? Or, does one try them all at once? This site merely leads to more questions rather than answers. Another frustrating issue is that the author/editor does not respond to questions or comments! I think that is irresponsible.

  • Teresa A.

    Oh my I’ve been on antidepressants since I was 18 yrs old when my father got killed. I’ve been on everything where it quit working or wasn’t the right one. I so deeply feel miserable all the time and no energy or interest in anything I feel like I’m in this deep black hole that I can seem to get out of. I can’t remember anything or concentration is horrible.Im 51 yrs old and just always feel so bad Can u please hel me so tired of feeling this way

  • Teresa, I have been doing some research due to the fact that my family seems to run low on dopamine and antidepressants do not typically zone in on that neurotransmitter. What prompted me to look into Mirapex (Parkinsons med) was because my 59 yr old sister has suffered from depression and anxiety for years and then developed Restless Leg Syndrome. She was prescribed Mirapex which raises dopamine and found that she is no longer depressed! I looked it up and it is used for depression when nothing else works. You may have to print an article and show your doctor if interested. I just thought I would share that info. I am sorry that you are suffering.

  • Agree with other comments: OUR COMMENTS DESERVE RESPONSES> it is wrong that these articles lack basic info & it is irresponsible to publish supplement info yet not advise if unsafe to take all 4 types. And this site should tell us how to find SAFE supplements – not all have the correct dosages.

  • I have just been put on SELEGILINE HCL 5mg twice a day. Am wondering if I can take powered mucuna with this medicine which increase dopa production in the brain. And get off SELEGILINE.
    Its for pre-parkinson’s

  • I don’t understand why so many ask how to find supplements or want more info. All you have to do is google any one of the recommended herbs/vitamins/drugs and you will get 1000+ links returned. Go to a large vitamin sales site like Amazon or Swanson and search and you get these products for sale.

  • Kurt H.

    I am 66 and I have suffered severe depression and/or bipolar disease. I am being treated by the Univ. of NM Dept. of Psychiatry. I have tried EVERY drug available and have attempted suicide three times. Two and a half days ago I saw two psychiatrists and it was suggested that I should try a Parkinson Disease Medicine; WOW!!!!!!!!!! It is helping as if Jesus had touched me! Anxiety, Bleak hopeless depression have lifted. I am not at the full prescription level, but I am simply astonished! I was giving up and was thinking about ECT and mentioned that to the attending psychiatrist! This is really seeming to be helpful! The FIRST effective drug! And I’ve tried just about everything else.

  • Alex v.

    Kurt! That is really really interesting! Thank you for posting and I’m thrilled you’re doing well!

  • Jigna P.

    @Kurt H. What is the medication that you tried? I also suffer from severe depression and have tried everything I can think of. I am so happy to hear that something worked for you, it gives me hope.

  • When taking dopamine supplements for treatment of Parkinson’s decease – do you take a combination of all four (L-Tyrosine, Dopa Mucuna, L-Theanine and Rhodiola) or only one of these at a time?

  • Melelina

    These things are trial and error. Go on Amazon and look up each supplement. Also, read the reviews. One brand of Rhodiola is said to work better than another brand of Rhodiola, etc. In addition, doctors are now saying we have a second brain in our gut that produces neurotransmitters also. Be sure to add probiotics supplements and switch brands every six months.

  • It says right in the text to try each one separately. I personally am looking for better Unity Consciousness and am trying green tea…<3

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