Dopamine Supplements May Improve Depression Symptoms, Mood, and Motivation

Got a case of the the blahs? You may have low dopamine levels. Fortunately, you can correct dopamine deficiency yourself by using one or more of these four top-researched dopamine supplements.

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Certain mood boosting vitamins, especially zinc, vitamin B6, and folate, are necessary for dopamine synthesis and neurotransmission.

© Tero Vesalainen | iStock/GettyImages Plus

When we think about depression, lack of motivation, or difficulty focusing and concentrating, the well-known brain chemical serotonin often comes to mind. While it’s true that serotonin deficiency is a problem for many people with depression and other mental health issues, researchers have known for years that other neurotransmitters such as dopamine are also involved. Fortunately, a dopamine deficiency can be effectively treated by using a number of dopamine supplements.

A well-covered study published in JAMA Psychiatry reported that people with clinical depression have significantly lower brain levels of dopamine.[1] Since then, we’ve learned a lot about dopamine’s role in mood and mental health—and also about the role of dopamine supplements in restoring low dopamine levels.

Loss of pleasure, loss of motivation, and not having enough focus or concentration to get things done can all be dopamine deficiency symptoms, as can the characteristic “slowness” of many people with depression. While most pharmaceutical drugs designed to increase dopamine are associated with significant and serious adverse effects, scientists have discovered and clinically tested a number of natural dopamine supplements that can safely increase dopamine levels within the brain and are generally without side effects. Natural and integrative physicians have been successfully using these ingredients to help patients with depression, anxiety, low motivation, and other low dopamine symptoms.

What Is Dopamine and What Are Dopamine Supplements?

Dopamine normally gets triggered when you approach and expect a reward. With the dopamine drug released in your brain, comes a good feeling and a surge of energy so you can reach your reward. Dopamine motivates you to seek, alerts your attention to things that meet your needs, and motivates you to persist in your pursuit of those things that meet your needs.

Your brain rewards you with dopamine each time you take steps towards a new goal. Without enough dopamine, your motivation goes kaput and you’re unable to experience pleasure from activities usually found enjoyable—e.g. exercise, hobbies, music, sexual activities, or social interactions. In other words, dopamine deficiency causes a bad case of the “blahs.”

The four dopamine supplements presented here—L-Tyrosine, Rhodiola, Mucuna, and L-theanine—have each been found in studies to increase dopamine and/or help balance dopamine function in the brain. They can be used as natural dopamine boosters to improve and enhance mood and motivation and to treat dopamine deficiency symptoms like depression, fatigue, lack of interest in life, poor memory, and impulsive behaviors.

1. L-tyrosine—Dopamine Booster

The conditionally essential amino acid tyrosine is a precursor of catecholamine neurotransmitters, including dopamine. It can be taken through your diet (especially from meat, eggs, and fish) or synthesized in the body. Tyrosine forms DOPA, which is then converted to dopamine, and this, in turn, forms norepinephrine, another neurotransmitter related to mood.

By supporting production of neurotransmitters like dopamine, L-tyrosine supplements can enhance mood, sleep, emotional well-being, and cognitive/mental function, especially under situations involving environmental and emotional stress or when dopamine levels require additional support. (Some people are genetically programmed to make too little dopamine.)[2-4]

Start by taking one 500 mg capsule of L-tyrosine. If you feel no benefits within 30 minutes, take a second capsule, and a third in another 30 minutes if you still feel nothing. Continue by taking one to three 500 mg capsules two or three times a day: early morning, mid-morning, and mid-afternoon. Decrease the dose if you feel agitated or your blood pressure increases.

2. Mucuna, L-DOPA Supplements

Mucuna pruriens, commonly known as velvet bean, naturally contains up to 5 percent L-DOPA (levodopa). L-DOPA supplement is the same biochemical that is made in humans from the amino acid L-tyrosine and is then synthesized into dopamine. When taken as a supplement, L-DOPA from mucuna can cross the blood-brain barrier to elevate brain dopamine levels.

Powdered mucuna seeds have long been used in Indian traditional medicine as support in the treatment of various illnesses, including Parkinson’s. Studies utilizing mucuna supplements have shown promising results not just for Parkinson’s but for other conditions related to dopamine deficiency, including depression and psychological stress.[5-7]

Mucuna extract has been shown to increase not only dopamine concentrations but also other neurotransmitters that affect mood, such as serotonin and norepinephrine.[8] Look for an extract of Mucuna pruriens standardized to contain 15 percent L-Dopa. Take 300 mg twice a day.

3. L-theanine

L-theanine is an amino acid uniquely found in green tea that creates an alert state of relaxation without drowsiness. L-theanine is known to be able to cross the blood-brain barrier and increase dopamine levels in the brain. Animal studies show that L-theanine also increases brain serotonin and GABA. It has antidepressant and anti-anxiety effects, reduces mental and physical stress, and leads to improvements in learning and memory in humans and animals.[9,10] Even just a single, small dose of L-theanine (100 mg) significantly improves the ability to pay attention and maintain focus compared to placebo.[11] Take 200 mg of L-theanine two to three times daily.

4. Rhodiola

Rhodiola rosea, or “golden root,” is a popular plant in traditional medicine in Eastern Europe and Asia. It has a reputation for improving depression, enhancing work performance, eliminating fatigue, and treating symptoms resulting from intense physical and psychological stress. Rhodiola exerts its benefits via multiple effects on the central nervous system—enhancing the stability of dopamine, for example, and supporting its reuptake. This leads to notable decreases in depression, anxiety, and fatigue as well as an increased ability to handle stress.[12]

In human studies, rhodiola has been shown to significantly reduce depression, anxiety, and stress-related fatigue compared to placebo.[13-15] Look for a rhodiola extract derived from Rhodiola rosea root and standardized to contain 3 percent total rosavins and a minimum 1 percent salidrosides. Take 170 mg twice a day.

Don’t Forget Multivitamins for Natural Mood Enhancers

Certain mood boosting vitamins, especially zinc, vitamin B6, and folate, are necessary for dopamine synthesis and neurotransmission. These nutrients are often depleted in individuals due to medications, inadequate diets, excessive stress, and toxic environmental exposures, compromising the ability to properly synthesize neurotransmitters like dopamine.

High-potency, high-quality multivitamin/mineral supplements can be natural mood enhancers. They can help replenish these co-factors, enhancing neurotransmitter function and playing a complementary role in supporting emotional wellness.

Potential Side Effects, Precautions, and Drug Interactions with Mood Boosters

Of course, too much dopamine is dangerous. Do not take more than one dopamine supplement at a time without first consulting with a healthcare practitioner, preferable one trained in integrative or natural medicine.

Similarly, do not use these dopamine supplements if you are taking methyldopa, antidepressants, or antipsychotic drugs without first consulting a physician. Tyrosine and mucuna pruriens may also interact with some nutritional supplements, including St. John’s Wort, 5-HTP, Tryptophan, and SAM-e. Therefore, you should also consult your healthcare practitioner before combining these supplements.

Do not take these supplements if you are a pregnant or lactating woman.

Additional Ways to Increase Dopamine

Besides taking dopamine supplements, there are other ways to naturally increase dopamine. For instance, do you know which foods are natural dopamine boosters and which foods can deplete dopamine? As Jami Cooley notes in Dopamine Deficiency: 8 Ways to Naturally Overcome Depression, “Bananas, especially ripe bananas, are an exceptional food for regulating dopamine because they have a high concentration of tyrosine. Other foods that increase dopamine through the conversion of phenylalanine to tyrosine include almonds, apples, watermelons, cherries, yogurt, beans, eggs and meats.”

Working toward a goal can also increase dopamine. By repeating small steps to reach a goal, you can rewire the dopamine pathways in your brain, ultimately teaching your brain to give you a dopamine surge every time you take that small step. You can also increase dopamine by developing an active and regular stress-reduction practice.[16]

Also, be sure to read about serotonin deficiency and serotonin supplements.

Originally published in 2013, this post has been regularly updated.

[1] Arch Gen Psychiatry. 2000 Aug;57(8):787-93.
[2] Biol Psychiatry. 2005 May 1;57(9):999-1003.
[3] C R Acad Sci III. 1988;306(3):93-8.
[4] Altern Med Rev. 2009 Jun;14(2):114-40.
[5] Evid Bas Comp Alt Med. 2010;7(1):137-144.
[6] Inventi Impact Ethnopharm. 2013;797.
[7] Pharm online. 2010;1:537-551.
[8] Orient Pharm Exp Med. 2013 Jun;13(2):143-148.
[9] Phytother Res. 2011 Nov;25(11):1636-9.
[10] Nutr Neurosci. 2013 Jul 23.
[11] Neuropharmacology. 2012 Jun;62(7):2320-7.
[12] Phytother Res. 2007 Jan;21(1):37-43.
[13] Nord J Psychiatry. 2007;61(5):343-8.
[14] Altern Complement Med. 2008 Mar;14(2):175-80.
[15] Planta Med. 2009 Feb;75(2):105-12.
[16] Neurosci Lett. 2010 Jul 26;479(2):138-42.


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Kathleen Jade, ND

Dr. Kathleen Jade is a naturopathic physician and served for many years as the Medical Director and Editor-In-Chief of Natural Health Advisory Institute. She has been licensed as a primary … Read More

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