Dopamine Supplements May Improve Depression Symptoms, Mood, and Motivation

Got a case of the the blahs? You may have low dopamine levels. Fortunately, you can correct dopamine deficiency yourself by using one or more of these four top-researched dopamine supplements.

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Certain mood boosting vitamins, especially zinc, vitamin B6, and folate, are necessary for dopamine synthesis and neurotransmission.

© Tero Vesalainen | iStock/GettyImages Plus

When we think about depression, lack of motivation, or difficulty focusing and concentrating, the well-known brain chemical serotonin often comes to mind. While it’s true that serotonin deficiency is a problem for many people with depression and other mental health issues, researchers have known for years that other neurotransmitters such as dopamine are also involved. Fortunately, a dopamine deficiency can be effectively treated by using a number of dopamine supplements.

A well-covered study published in JAMA Psychiatry reported that people with clinical depression have significantly lower brain levels of dopamine.[1] Since then, we’ve learned a lot about dopamine’s role in mood and mental health—and also about the role of dopamine supplements in restoring low dopamine levels.

Loss of pleasure, loss of motivation, and not having enough focus or concentration to get things done can all be dopamine deficiency symptoms, as can the characteristic “slowness” of many people with depression. While most pharmaceutical drugs designed to increase dopamine are associated with significant and serious adverse effects, scientists have discovered and clinically tested a number of natural dopamine supplements that can safely increase dopamine levels within the brain and are generally without side effects. Natural and integrative physicians have been successfully using these ingredients to help patients with depression, anxiety, low motivation, and other low dopamine symptoms.

What Is Dopamine and What Are Dopamine Supplements?

Dopamine normally gets triggered when you approach and expect a reward. With the dopamine drug released in your brain, comes a good feeling and a surge of energy so you can reach your reward. Dopamine motivates you to seek, alerts your attention to things that meet your needs, and motivates you to persist in your pursuit of those things that meet your needs.

Your brain rewards you with dopamine each time you take steps towards a new goal. Without enough dopamine, your motivation goes kaput and you’re unable to experience pleasure from activities usually found enjoyable—e.g. exercise, hobbies, music, sexual activities, or social interactions. In other words, dopamine deficiency causes a bad case of the “blahs.”

The four dopamine supplements presented here—L-Tyrosine, Rhodiola, Mucuna, and L-theanine—have each been found in studies to increase dopamine and/or help balance dopamine function in the brain. They can be used as natural dopamine boosters to improve and enhance mood and motivation and to treat dopamine deficiency symptoms like depression, fatigue, lack of interest in life, poor memory, and impulsive behaviors.

1. L-tyrosine—Dopamine Booster

The conditionally essential amino acid tyrosine is a precursor of catecholamine neurotransmitters, including dopamine. It can be taken through your diet (especially from meat, eggs, and fish) or synthesized in the body. Tyrosine forms DOPA, which is then converted to dopamine, and this, in turn, forms norepinephrine, another neurotransmitter related to mood.

By supporting production of neurotransmitters like dopamine, L-tyrosine supplements can enhance mood, sleep, emotional well-being, and cognitive/mental function, especially under situations involving environmental and emotional stress or when dopamine levels require additional support. (Some people are genetically programmed to make too little dopamine.)[2-4]

Start by taking one 500 mg capsule of L-tyrosine. If you feel no benefits within 30 minutes, take a second capsule, and a third in another 30 minutes if you still feel nothing. Continue by taking one to three 500 mg capsules two or three times a day: early morning, mid-morning, and mid-afternoon. Decrease the dose if you feel agitated or your blood pressure increases.

2. Mucuna, L-DOPA Supplements

Mucuna pruriens, commonly known as velvet bean, naturally contains up to 5 percent L-DOPA (levodopa). L-DOPA supplement is the same biochemical that is made in humans from the amino acid L-tyrosine and is then synthesized into dopamine. When taken as a supplement, L-DOPA from mucuna can cross the blood-brain barrier to elevate brain dopamine levels.

Powdered mucuna seeds have long been used in Indian traditional medicine as support in the treatment of various illnesses, including Parkinson’s. Studies utilizing mucuna supplements have shown promising results not just for Parkinson’s but for other conditions related to dopamine deficiency, including depression and psychological stress.[5-7]

Mucuna extract has been shown to increase not only dopamine concentrations but also other neurotransmitters that affect mood, such as serotonin and norepinephrine.[8] Look for an extract of Mucuna pruriens standardized to contain 15 percent L-Dopa. Take 300 mg twice a day.

3. L-theanine

L-theanine is an amino acid uniquely found in green tea that creates an alert state of relaxation without drowsiness. L-theanine is known to be able to cross the blood-brain barrier and increase dopamine levels in the brain. Animal studies show that L-theanine also increases brain serotonin and GABA. It has antidepressant and anti-anxiety effects, reduces mental and physical stress, and leads to improvements in learning and memory in humans and animals.[9,10] Even just a single, small dose of L-theanine (100 mg) significantly improves the ability to pay attention and maintain focus compared to placebo.[11] Take 200 mg of L-theanine two to three times daily.

4. Rhodiola

Rhodiola rosea, or “golden root,” is a popular plant in traditional medicine in Eastern Europe and Asia. It has a reputation for improving depression, enhancing work performance, eliminating fatigue, and treating symptoms resulting from intense physical and psychological stress. Rhodiola exerts its benefits via multiple effects on the central nervous system—enhancing the stability of dopamine, for example, and supporting its reuptake. This leads to notable decreases in depression, anxiety, and fatigue as well as an increased ability to handle stress.[12]

In human studies, rhodiola has been shown to significantly reduce depression, anxiety, and stress-related fatigue compared to placebo.[13-15] Look for a rhodiola extract derived from Rhodiola rosea root and standardized to contain 3 percent total rosavins and a minimum 1 percent salidrosides. Take 170 mg twice a day.

Don’t Forget Multivitamins for Natural Mood Enhancers

Certain mood boosting vitamins, especially zinc, vitamin B6, and folate, are necessary for dopamine synthesis and neurotransmission. These nutrients are often depleted in individuals due to medications, inadequate diets, excessive stress, and toxic environmental exposures, compromising the ability to properly synthesize neurotransmitters like dopamine.

High-potency, high-quality multivitamin/mineral supplements can be natural mood enhancers. They can help replenish these co-factors, enhancing neurotransmitter function and playing a complementary role in supporting emotional wellness.

Potential Side Effects, Precautions, and Drug Interactions with Mood Boosters

Of course, too much dopamine is dangerous. Do not take more than one dopamine supplement at a time without first consulting with a healthcare practitioner, preferable one trained in integrative or natural medicine.

Similarly, do not use these dopamine supplements if you are taking methyldopa, antidepressants, or antipsychotic drugs without first consulting a physician. Tyrosine and mucuna pruriens may also interact with some nutritional supplements, including St. John’s Wort, 5-HTP, Tryptophan, and SAM-e. Therefore, you should also consult your healthcare practitioner before combining these supplements.

Do not take these supplements if you are a pregnant or lactating woman.

Additional Ways to Increase Dopamine

Besides taking dopamine supplements, there are other ways to naturally increase dopamine. For instance, do you know which foods are natural dopamine boosters and which foods can deplete dopamine? As Jami Cooley notes in Dopamine Deficiency: 8 Ways to Naturally Overcome Depression, “Bananas, especially ripe bananas, are an exceptional food for regulating dopamine because they have a high concentration of tyrosine. Other foods that increase dopamine through the conversion of phenylalanine to tyrosine include almonds, apples, watermelons, cherries, yogurt, beans, eggs and meats.”

Working toward a goal can also increase dopamine. By repeating small steps to reach a goal, you can rewire the dopamine pathways in your brain, ultimately teaching your brain to give you a dopamine surge every time you take that small step. You can also increase dopamine by developing an active and regular stress-reduction practice.[16]

Also, be sure to read about serotonin deficiency and serotonin supplements.

Originally published in 2013, this post has been regularly updated.

[1] Arch Gen Psychiatry. 2000 Aug;57(8):787-93.
[2] Biol Psychiatry. 2005 May 1;57(9):999-1003.
[3] C R Acad Sci III. 1988;306(3):93-8.
[4] Altern Med Rev. 2009 Jun;14(2):114-40.
[5] Evid Bas Comp Alt Med. 2010;7(1):137-144.
[6] Inventi Impact Ethnopharm. 2013;797.
[7] Pharm online. 2010;1:537-551.
[8] Orient Pharm Exp Med. 2013 Jun;13(2):143-148.
[9] Phytother Res. 2011 Nov;25(11):1636-9.
[10] Nutr Neurosci. 2013 Jul 23.
[11] Neuropharmacology. 2012 Jun;62(7):2320-7.
[12] Phytother Res. 2007 Jan;21(1):37-43.
[13] Nord J Psychiatry. 2007;61(5):343-8.
[14] Altern Complement Med. 2008 Mar;14(2):175-80.
[15] Planta Med. 2009 Feb;75(2):105-12.
[16] Neurosci Lett. 2010 Jul 26;479(2):138-42.


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Kathleen Jade, ND

Dr. Kathleen Jade is a naturopathic physician and served for many years as the Medical Director and Editor-In-Chief of Natural Health Advisory Institute. She has been licensed as a primary … Read More

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  • Taking these supplements can also help decrease cravings for sugar or alcohol. That’s because low dopamine levels cause cravings, and sugar gives the false sense of “satisfying” that deficiency. Unfortunately, eating sugar or drinking alcohol will only further deplete dopamine levels in the brain. Thus, whether initiated by alcohol or sugar, the compulsive behavior addiction is the same – an undeniable desire for dopamine. So, taking these dopamine supplements will help fight this addictive dopamine depletion-sugar craving cycle!

  • Sorry I av low motivation rhodiola has no positive effects on me -it actually makes me tired and irritable etc. tyrosine has had a minimal effect in some ways but not with motivation. I will try the others.
    Sam Webster

  • I Would like to Order these Meds to help me recover from a Back Injury and pain Meds. We’re do I get the Meds from ?
    Thank you

  • I have learned that low dopamine levels can also effect a person’s eating patterns; if a person has a low dopamine level, they are never satisfied and always hungry. Have you heard of this before?

  • Oh my I’ve been on antidepressants since I was 18 yrs old when my father got killed. I’ve been on everything where it quit working or wasn’t the right one. I so deeply feel miserable all the time and no energy or interest in anything I feel like I’m in this deep black hole that I can seem to get out of. I can’t remember anything or concentration is horrible.Im 51 yrs old and just always feel so bad Can u please hel me so tired of feeling this way

  • Teresa, I have been doing some research due to the fact that my family seems to run low on dopamine and antidepressants do not typically zone in on that neurotransmitter. What prompted me to look into Mirapex (Parkinsons med) was because my 59 yr old sister has suffered from depression and anxiety for years and then developed Restless Leg Syndrome. She was prescribed Mirapex which raises dopamine and found that she is no longer depressed! I looked it up and it is used for depression when nothing else works. You may have to print an article and show your doctor if interested. I just thought I would share that info. I am sorry that you are suffering.

  • Agree with other comments: OUR COMMENTS DESERVE RESPONSES> it is wrong that these articles lack basic info & it is irresponsible to publish supplement info yet not advise if unsafe to take all 4 types. And this site should tell us how to find SAFE supplements – not all have the correct dosages.

  • I have just been put on SELEGILINE HCL 5mg twice a day. Am wondering if I can take powered mucuna with this medicine which increase dopa production in the brain. And get off SELEGILINE.
    Its for pre-parkinson’s

  • I don’t understand why so many ask how to find supplements or want more info. All you have to do is google any one of the recommended herbs/vitamins/drugs and you will get 1000+ links returned. Go to a large vitamin sales site like Amazon or Swanson and search and you get these products for sale.

  • I am 66 and I have suffered severe depression and/or bipolar disease. I am being treated by the Univ. of NM Dept. of Psychiatry. I have tried EVERY drug available and have attempted suicide three times. Two and a half days ago I saw two psychiatrists and it was suggested that I should try a Parkinson Disease Medicine; WOW!!!!!!!!!! It is helping as if Jesus had touched me! Anxiety, Bleak hopeless depression have lifted. I am not at the full prescription level, but I am simply astonished! I was giving up and was thinking about ECT and mentioned that to the attending psychiatrist! This is really seeming to be helpful! The FIRST effective drug! And I’ve tried just about everything else.

  • When taking dopamine supplements for treatment of Parkinson’s decease – do you take a combination of all four (L-Tyrosine, Dopa Mucuna, L-Theanine and Rhodiola) or only one of these at a time?

  • These things are trial and error. Go on Amazon and look up each supplement. Also, read the reviews. One brand of Rhodiola is said to work better than another brand of Rhodiola, etc. In addition, doctors are now saying we have a second brain in our gut that produces neurotransmitters also. Be sure to add probiotics supplements and switch brands every six months.

  • It says right in the text to try each one separately. I personally am looking for better Unity Consciousness and am trying green tea…<3

  • Oh I do hope one of these works for me ,mirapex .. Laura is this just in the USA? Cos in England, IV tried every antidepressant , my severe depression, anxiety , has gotten worse over the years, due to having had cancer at 21 and had to have a radical hysterectomy, so I’m 44 years old and have suffered from the menopause for 22 years and after losing my husband ago to cancer 4 years ago, nothing seems to work, before I lost my husband, every day I struggle battling this nasty disease, all I’d like to feel is up again and enjoy life… Kurt if you kindly tell us what Ty hey have put you on , the world be wonderful to know, cos I don’t think I can keep coping with feeling so low when , anybody who can help, I will love you forever, I’m desperate has the NHS in England, no one cares or in a hurry to help and when you have tried every single antidepressant in the last 11 years , I’ll take anything that’s natural or if anybody knows just of anything, I’m so so desperate not to feel helpless, worthless, tired but wired , I want to get up in the mornings and look forward to the day ahead instead of how my 3 son’s would be better of without me, anyone just anyone can give me some advice I really appreciate it. I hope you all find peace and to feel happy ♥️

  • Claire..Sorry to hear about your condition.. Hope you will get well soon. Ok , Now ,Buy Rhodiola Rosea supplements 500mg Caps.Take 1 when you wake up on empty stomach.per day. Its really good for what you describe your conditions. Look for 3%Rozavine and 1%Salidorane. (Should be written that on the bottle). Hope that helps, wish you the best..

  • Hate to read of so many suffering as I’ve done for 38 yrs – no medication, no therapy has ever helped and ashamed to ever speak of it as even family members struggle to understand or sadly seem disinterested and judgmental. Just recently started taking everything at levels that I believe would help based on my own judgment but not to over do it: L Tyrosine, Acetyl L-Carnitine, L-Dopa, Rhodiola, 1 tbls of raw apple cider vinegar with “mothers” for probiotics and many other proven benefits. I mix 2 energy-C powder packets in my water bottle each day. I have definitely noticed a difference in mood and energy the same day and seems to continue working after 2 weeks now. Don’t want to say how much I’ve taken of each, just look up each of these and what the daily recommendations are and decide for yourself how much you need. After reading more, I am also going to begin today with a quality B-complex as well as L-Thiamine. This is all experimental of course but I have to figure out how to increase my energy to basically function and even more – achieve goals because living this way is not acceptable to me and suicide will never be an option. I understand those feelings of desperation but life is too precious to give up – NEVER STOP TRYING!! In addition, get ahold of any kind of material that will help you to create new perceptions and the right mindset!! I know it’s cliche but only because it’s power is not truly understood. I have been filling my brain constantly-almost daily, with reading, audiobooks, youtube inspiration, my own daily mantras, etc for a few years now and it has made a world of difference. Lengthy, I know, but most people have no idea about this type of struggle so I hope the info is helpful.

  • Claire…with message July 21, 2018 HOW ARE YOU???
    …did the solution Shabal provided work?? I’m very interested to know how you’re doing…

  • Commenting on “Folly” …dear person, there are a million reasons why a person would not know how to do what you suggest. Arthritis is one, intimidation is another…just some of many. Please frame your suggestions in a positive framework that doesn’t suggest that your fellow posters are idiots. ALL PEOPLE want to be able to find information they need…and sometimes people need to come together to help support each other through the process…maybe sometimes people need is a little gentle guidance… But they definitely DO NOT NEED words shaming them. Thank you.

  • PLEASE READ THE WHOLE ARTICLE PG 6 warns that TOO MUCH DOPAMINE is dangerous. DO NOT take these 4 supplements at once. I am going to try Rhodiola upon recommendation of Shahbal from 9/7/18. Go under each supplement info for dosage info/read Shahbals comments.

  • I just wanted to add for all of you who commented who are suffering from depression (especially women) it might be worth your time to look into seeing if you have ADHD. I’ve suffered from depression and been on anti-depressants since age 18 but despite trying over 30 different brands/types I never found relief. It wasn’t until June 2016 when I changed psychologists and explained to my new doctor my symptoms (low energy, no motivation, extreme impulsivity, extreme guilt, feelings of hopelessness, forgetting things daily, frequently called lazy, etc.) that he diagnosed me with ADHD. Now that it’s been over 2 years and a lot of trial and error I’ve found a stimulant that works for me (Vyvanse) but no medication will be enough I also read, listen, watch (books, articles, podcasts, & videos) on how to be productive, suggestions for prioritizing, etc. Of course, I’m not suggesting that anyone try to self diagnose but if you do some research and find a lot of these traits seem to match you print out what you’ve found and take it to your doctor for an official diagnosis. Cognitive therapy also helps (unfortunately I don’t have insurance so it’s not an option for me right now). Best of luck!

  • Vyvanse (mentioned above) is classified as a “controlled substance” because of its propensity to cause addiction. It is commonly compared to Adderall although they are different from one another in their chemical makeup.

  • My GP had me on Paroxetine (SSRI), Risperidone (Atypical Anxiety), Sodium Valproate (mood stabiliser), Ativan (Benzo -sedative for panic) and Venlafaxine (SNRI) for panic when can’t take a benzo. Not to mention other medications for other ailments. In the past I have been prescribed Anti psychotics Risperidone, Stelazine, Olanzapine (not at the same time) by a Psychiatrist and of course they would endorse pharmaceuticals and boohoo natural alternatives as I’ve seen on ask a doctor type sites, giving opinion to those questions regarding using naturals. The Antipsychotics flattened me out. I was frustrated and at the end of my tether. It bothers me when clinicians start prescribing more and more meds and I was starting to get tremors, from long term drug use. Now I am not suggesting people go off meds, but I take 5-HTP, L theanine, L Tyrosine and St Johns Wort in place of without issue. Goodness knows the combination of the pharmaceuticals were impacting on my nervous system and probably interacting in a worse way. What also concerned me is apparently venlafaxine can mimic in the blood and show positive for methamphetamines even though it is not – imagine explaining that on a random drug test. Another reason for obtaining neurotransmitter support elsewhere.

  • Is L-DOPA safe? I am surprised that this article would suggest it for depression? From what I have read, L-Dopa (which is normally used to reduced parkinson’s symptoms) can induced Dyskinesia (which is the impairment of volountary movements and it’s poorly reversible)

  • @Sam M…what are you talking about L-dopa is safe?? Didnt this article suggest 4 natutal supplements called L-Tyrosine, Rhodiola, Mucuna, and L-theanine???

  • @sam. That may be caused by taking the potent drug form that is precribed. In the article it states these are 4 natural alternatives that have little to no side effects:

    “While most pharmaceutical drugs designed to increase dopamine are associated with significant and serious adverse effects, scientists have discovered and clinically tested a number of natural dopamine supplements that can safely increase dopamine levels within the brain and are generally without side effects”

  • I took Flupentixol injection, it lowered my consciousness and my sex drive, please how do I get these back

    • Hi G, because we can’t provide individualized medical advice, it’s best to contact your doctor directly. Thanks!

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