What Is Adrenal Fatigue? Watch for These Symptoms

Adrenal gland dysfunction is largely overlooked in conventional medicine, and yet it is pervasive and contributes to dozens of health problems. Here's how to know whether you have it—and if so, what to do about it.

By UHN Staff • April 5, 2017

Weakness, depression, apathy, and feeling constantly tired are among the symptoms of adrenal fatigue.

Are you besieged by fatigue plus one or more nagging other problems, such as insomnia, weight gain, or depression? If so, you could be suffering from adrenal fatigue.

Specific lab tests are available to confirm an adrenal dysfunction problem, but just knowing the typical adrenal fatigue symptoms is often quite sufficient to confirm it as the likely root cause of your issues.

If you see your own symptoms matching that of the typical “textbook” symptoms, then you can begin to take some straightforward natural healing steps to strengthen your adrenal glands and restore balance to your system. Not only will your energy level return, but you may be amazed to see your sleep problems and depression and other issues go away as well.

What is Adrenal Fatigue?

Adrenal fatigue, or hypothalamic pituitary adrenal axis dysfunction, is a major underlying cause of many seemingly unrelated chronic health problems, and it is often misdiagnosed. We want to explore here what adrenal fatigue is and what symptoms are typical in individuals who suffer from it.

Adrenal fatigue symptoms are more appropriately referred to as symptoms of poorly functioning HPA axis. The HPA axis is your body’s hormonal response system to chronic stress. “HPA” refers to three hormone-secreting glands, the hypothalamus and the pituitary gland in the brain, and the adrenal glands, which sit on top of the kidneys.

Situations that are new, unpredictable, threatening, or uncontrollable activate the HPA axis to mobilize energy necessary to adapt to the demands of the situation.

When your body is bombarded by repeated stressful situations and prolonged stress responses, you pay a price. Your HPA axis can start to under-react or overreact to stress, or may function in inappropriate rhythms. This, in turn, taxes your body’s nervous, hormonal, immune, metabolic, and cardiovascular systems, causing fatigue, insomnia, and a variety of other physical and psychological symptoms that are generally known as adrenal fatigue symptoms or hpa dysfunction symptoms.

Adrenal Fatigue Symptoms

HPA axis dysfunction symptoms are caused by stress and can include a feeling of persistent, excessive tiredness and a lack of energy that just doesn’t seem to go away no matter how much sleep you get. In addition to fatigue, adrenal fatigue symptoms include one or more of the following:

Weakness
Muscle pain
Joint pain
Sore throat
Headaches
Dizziness upon standing
Increased heart rate
Appetite changes
Bowel/stool changes
Abdominal pain
Depression
Apathy
Irritability
Sleep disturbances
Difficulty concentrating
Difficulty with memory
Confusion
Anxiety
Sleepiness

Many studies have examined the relationship between adrenal fatigue anxiety, stress, HPA-axis activity, and fatigue. People with chronic fatigue syndrome (CFS), for instance, report experiencing significantly higher levels of stress. Studies have found that those with CFS do, indeed, have significantly more exposure to stressors.

In patients with CFS, dysfunction of the HPA axis (characterized by lower-than-normal cortisol secretion) is one of the hallmark features, and studies have shown that the lower the cortisol levels, the more severe the fatigue and other symptoms.

Conditions Related to HPA Axis Dysfunction

In addition to chronic fatigue syndrome, a number of other fatigue-related conditions, such as fibromyalgia, post-traumatic stress disorder, and some types of depression, are associated with stress and a poorly functioning HPA axis. Other conditions related to HPA axis dysfunction and associated with adrenal fatigue symptoms include:

Depression
Anorexia nervosa
Obsessive-compulsive disorder
Panic disorder
Chronic, active alcoholism
Diabetes mellitus
Central obesity (metabolic syndrome)
Post-traumatic stress disorder
Chronic fatigue syndrome
Fibromyalgia
Premenstrual tension syndrome
Postpartum period
Rheumatoid arthritis
Asthma, eczema

Even in those who are otherwise healthy, studies have found that if you perceive yourself to be highly stressed, you are much more likely to suffer from greater fatigue, sleep problems, and other adrenal fatigue symptoms. For example, work-related stress—as caused by over-commitment, lack of social support, high demands, lack of control, and lack of rewards—has been shown in studies to drain energy resources and cause fatigue.

So it’s clear here that unrelenting stress can and does have a direct physiologic effect on the body. Your HPA axis becomes dysfunctional and the end result is the occurrence of these bothersome adrenal fatigue symptoms.

How to Fix Adrenal Fatigue

The key to overcoming your adrenal fatigue symptoms is to break the dysfunctional HPA axis cycle, getting the hypothalamus, pituitary, and adrenal glands re-balanced and working in harmony again. This is where natural and integrative approaches really shine.

What works best for treating adrenal fatigue symptoms is a holistic approach involving diet, sleep, relaxation, exercise, and supplements. Pharmaceutical intervention is typically not necessary. Find stress management techniques here and effective ways to de-stress here.

[1] Biol Psychol. 2009 Oct;82(2):149-55.

[2] Psychoneuroendocrinology. 2005;30(10): 1010–1016.

[3] Psychoneuroendocrinology. 2012 May;37(5):671-84.

[4] Appl Psychol. 2011 May;96(3):654-64.

[5] Stress. 2012 Jan;15(1):45-51.

[6] Psychoneuroendocrinology. 2009 Nov;34(10):1476-85.

[7] Psychoneuroendocrinology. 2008 May;33(4):471-7.

[8] Psychol Bull. 2007 Jan;133(1):25-45.

[9] Psychiatry Res. 2011 Sep 30;189(2):318-20.

[10] Nat Rev Endocrinol. 2011 Sep 27;8(1):22-32.

[11] Psychol Med. 2010 Mar;40(3):515-22.

[12] Occup Environ Med. 2012 Jun;69(6):377-84.