Anaplasmosis: Tick-Borne Disease Is Gearing Up and On the Rise

The tick-borne bacterial disease anaplasmosis is gaining ground on Lyme disease. Here, we identify the symptoms and offer treatment and prevention tips.


Most healthy individuals recover fully from anaplasmosis with treatment. Older people can be at a high risk of more serious effects.

© Heiko Barth |

Ticks are nasty bugs that transmit a number of diseases, among them anaplasmosis. What is anaplasmosis? It’s caused by the bacteria Anaplasma phagocytophilum, which the tick shares when it bites a host. Anaplasmosis is the second-most common tick disease, after Lyme disease.

Symptoms | Treatment | Prevention

While the incidence of Lyme disease dwarfs that of anaplasmosis (30,000 Lyme cases to 4,461 anaplasmosis), the Centers for Disease Control and Prevention (CDC) states that anaplasmosis is on a rapid incline, from 348 reported cases in 2000 to 4,415 reported cases in 2016. Anaplasmosis affects not only humans, but dogs, cats, horses, cattle, and sheep.

Anaplasmosis symptoms usually appear one to two weeks after a tick bite. A rash can occur with anaplasmosis, but it’s often a signal that another pathogen is at work as well, such as Lyme disease.

Anaplasmosis Symptoms


If you discover a tick bite on your body, be alert to the symptoms of anaplasmosis, as described here.

Symptoms of anaplasmosis may include:

  • Chills
  • Confusion
  • Cough
  • Fever
  • Headache
  • Malaise
  • Muscle pain
  • Nausea/Abdominal pain

Because these symptoms are general and overlap so many other diseases, physicians often make an anaplasmosis diagnosis based on assumption, as in evidence or knowledge of a tick bite or being in a tick-infested area. Blood tests can’t pinpoint the bacteria, as they won’t show up for seven to 10 days. However, a complete blood count and a liver function panel could show low platelet counts, low white blood cell counts, and/or elevated liver enzyme levels, which would be used as additional signs of possible anaplasmosis.

Most healthy individuals recover fully from anaplasmosis with treatment. Older people, though, can be at a high risk of more serious effects.

According to St. Luke’s Health System in Kansas City, anaplasmosis complications “are more common in those who have weak immune systems. This includes people who have AIDS, cancer, or organ transplants. They may need additional treatments, such as fluids, breathing support, or kidney dialysis. In a small number of people, these complications can lead to death.”


Although the Centers for Disease Control and Prevention state that only 1 percent of anaplasmosis cases become fatal, it’s a sobering thought—and impetus to get to the doctor immediately if you’ve been bitten by a tick and start experiencing the symptoms described in this post.

Treatment for Anaplasmosis

Doxycyline is usually prescribed based on symptoms of a tick-borne disease like anaplasmosis. The sooner the course of antibiotics is started, the better in getting rid of the illness. Doxycline belongs to the tetracyline group of antibiotics, which are effective on bacterial infections like anaplasmosis and Lyme disease.

Some people have trouble taking doxycline for anaplasmosis or any other bacterial infection. Among the drug’s side effects are a loss of appetite, nausea, and vomiting.  If you cannot keep the pill down, report that immediately to your physician, because you won’t get any benefits. Mild side effects from the drug may go away within a week or so if you can tolerate them, but serious side effects—bloody diarrhea, cramping, headaches, vision problems—should be reported to your doctor immediately, according to

Tick Travel


A view of a tick’s underside; note the mouth parts, through which a tick passes along such diseases as anaplasmosis and Lyme.

Ticks can’t jump or fly, whether they’re carrying anaplasmosis or any other disease. They hold onto a blade of grass, waiting transfer to a host who is close enough to crawl onto. Once they are aboard, they walk around, looking for a place with thinner skin and, usually, hair. Ticks are often found on the head, pubic hair, armpit, ears, bellybutton, and back of the knees. According to the CDC, they begin to feed 10 minutes to 24 hours after landing on a host.

This timing is critical. While many sites say it takes 24 to 48 hours for the transmission of a disease like anaplasmosis to occur, some experts have cited timelines as low as a few hours. One thing is clear: Once the tick begins to feed, it can transfer disease.

Any stage of a tick’s life may be capable of transferring diseases like anaplasmosis. “Most ticks go through four life stages: egg, six-legged larva, eight-legged nymph, and adult. After hatching from the eggs, ticks must eat blood at every stage to survive,” says the CDC.

Here’s how to remove a tick if you find one attached to you, per the Centers for Disease Control and Prevention:

  1. Use fine-tipped tweezers to grasp the tick as close to the skin’s surface as possible.
  2. Pull upward with steady, even pressure. Don’t twist or jerk the tick; this can cause the mouth-parts to break off and remain in the skin. If this happens, remove the mouth-parts with tweezers. If you are unable to remove the mouth easily with clean tweezers, leave it alone and let the skin heal.
  3. After removing the tick, thoroughly clean the bite area and your hands with rubbing alcohol or soap and water.
  4. Never crush a tick with your fingers. Dispose of a live tick by putting it in alcohol, placing it in a sealed bag/container, wrapping it tightly in tape, or flushing it down the toilet.

Preventing Anaplasmosis

Although your dogs, cats, horses, and other animals can also contract anaplasmosis from a tick bite, anaplasmosis is not contagious. It is only transferred by that bug bite. Therefore, preventing anaplasmosis involves reducing your chance of picking up a tick.

Know that ticks hide mainly in tall grass and brushy, wooded areas, but they are not confined to the woods. You may find a tick in your own garden.

Spray permethrin (0.5%) on clothing and gear (it may remain protective through several washings, says the CDC).  You can also purchase permethrin-containing clothing. Brands include ElimiTick, BugBeWear, InsectShield, Duluth Trading, LL Bean, ExOfficio, and Sawyer.

The University of Rhode Island conducted a controlled study to compare tick bites on people wearing permethrin-treated clothing vs. regular summer clothing, like T-shirts and shorts. They placed blacklegged ticks on 15 (very brave) volunteers. The results after the two-day trial confirmed that permethrin-treated, military-weight clothing was most effective against tick bites (dead ticks were found under some of these clothing) and that summer-weight non-treated clothing had the highest potential for tick-borne pathogen transmission.

Additional repellents that are effective include products containing DEET, picaridin, IR3535, oil of lemon eucalyptus (OLE), para-menthane-diol (PMD), and 2-undecanone. The Environmental Protection Agency (EPA) has a website page that can help you choose exactly the right type of repellent for your outing.

Remember that ticks may be carried into your home, so always check for ticks as soon as you go inside. Doing a tick inspection on one another, showering, and changing clothes is always wise. The CDC advises: “Tumble-dry clothes in a dryer on high heat for 10 minutes to kill ticks on dry clothing after you come indoors. If the clothes are damp, additional time may be needed. If the clothes require washing first, hot water is recommended. Cold and medium temperature water will not kill ticks.”

Tick-Borne Illnesses in the USA

Illness Carrier Symptoms Locations
364D Rickettsiosis Pacific Coast tick Ulcerative skin lesion, fever, headache, fatigue, muscle aches California
Anaplasmosis Black-legged deer ticks, Western black-legged ticks Fever, chills, headaches, muscle aches. Upper midwestern and northern states, Pacific coast
Babesiosis Black-legged tick None to fever, chills, sweating, body aches, nausea, fatigue, headache, loss of appetite Northeast and upper Midwest
Borrelia miyamotoi Lack-legged deer tick, the western black-legged tick Fever, chills, headache, body and joint pain and fatigue Anywhere black-legged ticks are found
Bourbon virus Not determined, ticks and other biting insects Fever, fatigue, headache, rash, body aches, nausea, vomiting Rare; found in Midwest and southern United States
Colorado tick fever Rocky Mountain wood tick Fever, chills, headache, body aches, fatigue, sore throat, vomiting, abdominal pain, skin rash Rocky Mountain states at elevations of 4,000 to 10,500 feet
Ehrlichiosis Lone star tick Fever, headache, stomachache, cough, confusion, muscle aches, fatigue Mid-Atlantic, southeastern, and southern central states
Heartland Virus Lone star tick Fever, headaches, nausea, decreased appetite, fatigue, muscle aches, diarrhea Midwest and southern states
Lyme Disease Black-legged deer tick, western blacklegged tick Bulls-eye rash, fever, chills, body aches, headache, fatigue; can cause long-lasting neurological issues, cognitive impairment, joint inflammation, irregular heart rhythm Northeast, spreading into the upper Midwest, Pacific Coast
Powassan disease Black-legged tick, groundhog tick Fever, headache, vomiting, confusion, weakness, memory loss, seizures; can result in severe neurological problems and death. Northeast and Great Lakes region states
Rickettsia Parkeri Rickettsiosis Ticks and mites Fever, muscle pain, rash, scalp tenderness No specific area
Rocky Mountain Spotted Fever American dog tick, Rocky Mountain wood tick, brown dog tick Fever, headache, rash, muscle pain, inflammation of the brain, kidney failure, can be fatal Mid-Atlantic states, eastern and southern Arizona, and northern Mexico
Southern tick-associated rash illness (STARI) Lone star tick Similar to Lyme, fatigue, headache, fever, muscle pains
Tickborne relapsing fever (TBRF) Infected soft ticks (associated with rustic cabins and vacation homes) fever, fatigue, muscle and joint aches, vomiting, diarrhea, chills, and nausea Arizona, California, Colorado, Idaho, Kansas, Montana, Nevada, New Mexico, Ohio, Oklahoma, Oregon, Texas, Utah, Washington, and Wyoming
Tularemia Wood tick, dog tick, and lone star Skin ulcer, swollen lymph nodes, inflammation, cough, chest pain, difficulty breathing, death Atlantic coast, moving westward into Midwest and southern central states

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Cindy Foley

Cindy Foley is the editor of several health reports, including Managing Your Cholesterol, Core Fitness, and Brain Power & Nutrition, among others. Foley has worked in the private medical practice field … Read More

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