Small intestinal bacterial overgrowth (SIBO) is an increasingly recognized condition in which there is an elevated number of bacteria in the small intestines. The small intestine normally contains relatively few bacteria, but with SIBO, bacteria that are normally found in the colon—Escherichia coli, species of Enterococcus, Klebsiella pneumonia and Proteus mirabilis—abnormally expand into the small intestine.
These bacteria are notorious for fermenting carbohydrates into gas and their overgrowth is responsible for classic SIBO symptoms like gas and bloating. The good news is that SIBO treatment with either conventional or natural antibiotics is proven effective, especially if a SIBO diet is followed simultaneously.
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What are the symptoms of SIBO
The main SIBO pain and symptoms are digestive in nature, although some people with SIBO have no gastrointestinal-related symptoms at all. Digestion-related SIBO symptoms include:
- abdominal discomfort and pain
Because SIBO is associated with malabsorption of nutrients, many subtle and not-so-subtle symptoms of vitamin and mineral deficiencies may occur, including:
- joint and muscle pain
- neuropathy (tingling, numbness, or pain in the extremities).
In extreme SIBO cases, there may be obvious signs of malabsorption, including weight loss and excessive fat in the stool (steatorrhea).
Health conditions related to SIBO
A number of diseases are associated with SIBO, including the following:
- Irritable bowel syndrome
- Restless leg syndrome
- Macrocytic anemia (due to vitamin B12 deficiency)
- Microcytic anemia (due to bleeding ulcers)
- Liver diseases (cirrhosis and nonalcoholic hepatitis)
- Celiac disease
- Fibromyalgia 
- Parkinson’s disease 
- Hypothyroidism 
- Inflammatory bowel disease (ulcerative colitis and Crohn’s disease) 
- Chronic pancreatitis 
- Autoimmune disease (rheumatoid arthritis) 
- Chronic prostatitis 
What causes SIBO?
SIBO develops when the normal mechanisms that control balance among the gut bacteria are disrupted. One of the most common processes that leads to bacterial overgrowth syndrome symptoms is decreased gastric acid (hydrochloric acid) secretion. Many people, especially as they get older, don’t make enough hydrochloric acid to properly digest food in the stomach. Heartburn sufferers who regularly use antacids or proton pump inhibiting drugs (purple pill) are also at increased risk of SIBO. Another common cause of bacterial overgrowth is statis (dysmotility) in the gut, which allows the bacteria to proliferate because the contents of the gut do not get pushed through quickly enough. Irritable bowel syndrome and certain medications like pain killers (narcotics) and proton pump inhibitors are common causes of stasis, as are many of the conditions listed above. Once present, bacterial overgrowth may cause inflammation in the mucus lining of the intestine, further exacerbating SIBO and its typical symptoms.
Testing for SIBO
The gold standard for diagnosing SIBO is an invasive, expensive, and rarely used test in which contents are collected from the small intestine and the numbers of bacteria are directly measured. To make SIBO detection easier, breath tests are used instead. A number of breath tests are now available and are becoming commonplace in gastroenterologists’ clinics, although there is some disagreement as to which tests are the most accurate and exactly how they should be interpreted. The most common tests are hydrogen breath tests. Patients are given a specific amount and type of carbohydrate (usually in the form of glucose and lactulose) and then hydrogen concentrations in the breath are measured over a period of time. With SIBO, bacteria in the small intestines ferment these carbohydrates and hydrogen is produced.
Conventional SIBO treatment is currently limited to oral antibiotics with variable success. Typically, a short course (10-14 days) of rifaximin is used. Rifaximin is a unique antibiotic in that very little of it actually gets absorbed—most stays in the gastrointestinal tract. This means it is generally less toxic and therefore better tolerated than most antibiotics. However, rifaximin is extremely expensive and can still cause allergic reactions and/or a number of adverse effects, including, ironically, adverse effects on the gut microbiome. Perhaps most importantly, when used as the sole therapy, rifaximin’s success rate for SIBO treatment is only 49.5%. Repeated courses of the antibiotic frequently must be used.
Herbal antimicrobials and SIBO diet for eliminating SIBO symptoms
A recent study conducted by physicians at John’s Hopkins and the University of Pittsburgh, which you can read about in SIBO Treatment with Herbs Is as Effective as Antibiotics; Combine with a SIBO Diet for Even Better Results, found that SIBO treatment using herbal supplements containing combinations of herbs with antimicrobial properties was as effective as rifaximin. Many natural and integrative practitioners today are testing and treating patients for SIBO using combinations of conventional antibiotics, herbal antimicrobials, and other natural-based therapies, including various versions of the SIBO diet, which restricts carbohydrates for a limited time in order to reduce the bacteria’s food source. In part 2, learn about the best diets for eliminating SIBO symptoms and how diet can best be combined with herbal antimicrobials for the most effective natural SIBO treatment.