Niacinamide, a Gentler Form of Niacin, Has Positive Benefits on Skin, Eyes, and More

You can avoid the flushing side effect of niacin with niacinamide and possibly pick up some skin perks, too.


Niacinamide is often added to cosmetics for its ability to regulate oil flow, fight wrinkles, and reduce redness.

© Inara Prusakova | Dreamstime

Niacinamide is usually recommended over niacin as a supplement to treat pellagra (vitamin B3 deficiency) because it avoids the common side effect of flushing associated with niacin. However, because B supplements can result in toxic levels, it’s wise to consult your doctor or a nutritionist before adding any type of niacin supplement.

Niacinamide is not just a nutritional supplement, however. The cosmetics industry has embraced niacinamide as a topical. As a moisturizer, it’s used to combat aging and reduce rosacea. It is also widely used in a gel form to fight acne.  Ironically, it was through the use of niacinamide in people suffering from true B3 deficiency that its ability to help with skin and as an anti-aging ingredient was found.

Patti Farris, M.D. explains in Dermatology Times: “Niacinamide has become popular as a cosmeceutical ingredient. Cosmeceuticals contain three primary forms of vitamin B3, including niacinamide, nicotinic acid, and nicotinate esters. Niacinamide is the most well studied form of topical B3 and is generally regarded as the most efficacious. Niacinamide readily penetrates the stratum corneum and has a favorable tolerability profile, as it does not cause cutaneous irritation or flushing commonly seen with nicotinic acid. It can be used in formulations, at concentrations up to 5%, with a very low incidence of irritation.”


Rarely do we have a vitamin B deficiency, technically called “pellagra,” because most people’s diets include foods rich in B vitamins or B-vitamin fortified. Since B vitamins are water-soluble, they are not stored in your body and must be replenished daily preferably through food.  Pellagra most often occurs in people who are alcoholics or on a diet low in wheat, eggs, beef, poultry, or other niacin- or tryptophan-rich foods, according to Taber’s Cyclopedic Medical Dictionary. Treatment is an adequate diet with niacin or niacinamide.

Symptoms of pellagra include:

Anti-Anxiety Properties

Niacinamide is becoming a popular natural remedy for anxiety. A groundbreaking case report published in 2004 discussed a patient who moved from a pharmaceutical anti-anxiety medicine to niacinamide. In “Niacinamide’s Potent role in Alleviating Anxiety with its Benzodiazepine-like Properties: A Case Report,” author Jonathan E. Prousky, N.D., FRSH, described the stages his patient went through, trying various medicines and natural remedies for his anxiety.

In the end, the author concluded that, “This 34-year-old patient has been able to practice as a doctor without any impairments or restrictions and continues to do very well approximately 15 months . . . He no longer feels that anxiety is a problem and believes that the niacinamide is equally as effective as benzodiazepine medication, but is potentially safer to take for long-term use.”

This isn’t a suggestion for consuming too much niacinamide for anxiety. In excess amounts, it can cause nausea, cramps, diarrhea, and vomiting. Stick to recommended levels, and always consult your physician.

Hope for Glaucoma

A study from Jackson Laboratory, published in Science, found niacinamide prevents glaucoma in laboratory mice. They used mice genetically predisposed to glaucoma and added niacinamide to drinking water. The vitamin was surprisingly effective, eliminating the vast majority of age-related molecular changes and providing a remarkably robust protection against glaucoma.

In essence, the treatments of niacinamide kept aging retinal ganglion cells healthier for longer. “Because these cells are still healthy, and still metabolically robust,” says JAX Postdoctoral Associate Pete Williams, first author of the study, “even when high intraocular pressure turns on, they better resist damaging processes.”

Other Benefits of Niacinamide

According to the University of Maryland, niacinamide may help protect the pancreatic cells that make insulin, making it a possibility for type 1 diabetes, at least for a short time. More research is needed, and the protection does not move over to type 2 diabetes.  In fact, too much niacin can raise blood sugar in type 2 diabetics.

In a preliminary study, niacinamide increased joint mobility to the point that the subjects could take less non-steroidal anti-inflammatory medications (NSAIDs) to control arthritic pain. Again, this possibility needs more research.

Interestingly, niacin—but not niacinamide—can help lower blood cholesterol and has cardiovascular benefits. The University of Maryland made the point that many of the findings involving benefits of niacin are from dietary sources rather than supplements. Foods high in niacin include protein-rich turkey, beef, and salmon. Fortified cereals,  power bars, and energy drinks also provide even high vitamin B amounts per serving.

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Cindy Foley

Cindy Foley is the editor of several health reports, including Managing Your Cholesterol, Core Fitness, and Brain Power & Nutrition, among others. Foley has worked in the private medical practice field … Read More

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