Pancreatic Cancer Causes: What You Can Do to Reduce Your Risk

With no early warning signs of pancreatic cancer and no proven way to detect it in its earlier, more curable stages, prevention through lifestyle modification becomes paramount.

pancreatic cancer causes

By 2030, pancreatic cancer will become the second-leading cause of cancer deaths in the U.S., according to experts.

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Patrick Swayze. Steve Jobs. Luciano Pavarotti. Michael Landon. They’re just a few of the public figures who have succumbed to pancreatic cancer. In the vast majority of people it touches—rich or poor, famous or anonymous—pancreatic cancer causes death. In fact, while mortality rates for many other cancers are declining, deaths from pancreatic cancer are on the rise.

According to the American Cancer Society’s (ACS) Cancer Statistics 2016 report, pancreatic cancer is expected to supplant breast cancer this year as the third-leading cause of cancer-related deaths in the United States. Some experts predict that by 2030, pancreatic cancer will become the second-leading cancer killer in the U.S., behind only lung cancer.

The reason for these dire predictions isn’t because rates of pancreatic cancer are skyrocketing—it accounts for only about 2 percent of new cancer cases diagnosed in the U.S. annually (about 53,000 new diagnoses in 2016), according to the ACS.

“I wouldn’t say it’s [a matter of] increasing incidence as much as it is that we’re getting better at treating certain other cancers and finding other cancers at earlier stages,” says Rachna Shroff, MD, assistant professor of gastrointestinal medical oncology at the University of Texas MD Anderson Cancer Center. “Unfortunately, we have not made that progress with pancreatic cancer.”

So, until better detection and treatment strategies are identified, it’s up to you to avoid potential pancreatic cancer causes and reduce your risk.

No Signs of Pancreatic Cancer

One of the main reasons pancreatic cancer is so lethal is because it usually doesn’t cause symptoms until it has spread throughout the entire pancreas or beyond. At this point, patients may develop the following signs of pancreatic cancer:

  • Jaundice, which causes the skin and eyes to appear yellow and urine to darken
  • Abdominal pain (especially in the upper abdomen) and back pain
  • Loss of appetite; weight loss
  • Nausea and vomiting
  • Weakness

Keep in mind that because these symptoms are shared by other conditions, tests are needed to determine whether they’re due to pancreatic cancer. However, although several tests can be done to confirm the presence of pancreatic cancer, none of them have proven effective in detecting the disease in its infancy.

“We have no screening modality that finds it at earlier stages,” Dr. Shroff says. “There have been a number of investigations looking at different screening modalities, such as endoscopic ultrasound, but all of those studies of screening have been negative.

“About 80 percent of patients with pancreatic cancer present with advanced disease,” she continues. “Either it has grown too large within the pancreas that we cannot surgically remove it, which is the only curative therapy, or it has spread to other organs. Those patients are not curable, either. …Unfortunately, the overall five-year survival rate for pancreatic cancer of all stages is very low.”

Potential Pancreatic Cancer Causes

Given these alarming statistics and the poor prognosis for most people diagnosed with pancreatic cancer, reducing your risk of the disease becomes critical.

Researchers have identified a number of potential pancreatic cancer causes or factors that increase your likelihood of developing the disease. Age is one of them—about two-thirds of cases occur in people over age 65, the ACS says. The risk of the disease is also slightly higher in men and African-Americans, and is significantly greater in people with a family history of pancreatic cancer or certain inherited genetic syndromes (which account for as many as 10 percent of pancreatic cancer cases).

While you can’t change these risk factors, you can avoid other pancreatic cancer causes, such as smoking. The ACS estimates that smokers face twice the risk of pancreatic cancer as non-smokers, and that about 20 to 30 percent of pancreatic cancers are caused by smoking. If you smoke, ask your doctor about ways to quit.

“The No. 1 thing is smoking cessation,” Dr. Shroff emphasizes. “Everyone knows that it causes lung cancer. I don’t know that there’s a clear understanding of the fact that smoking increases your risk of pancreatic cancer.”

Being overweight or obese is among the other potential pancreatic cancer causes. In fact, obese people face about a 20 percent greater risk of pancreatic cancer compared to their normal-weight peers, the ACS notes. Obesity is a leading risk factor for type 2 diabetes, which also has been associated with increased pancreatic cancer risk. So, if you’re carrying excess weight, especially around your waistline, work with your healthcare team to lose weight through exercise and a healthful diet.

“There are so many different cancers that we know are associated with the ‘Western’ diet and lifestyle,” Dr. Shroff says. “What I tell everyone is take good care of yourself and your body. Don’t smoke, exercise regularly, take in a diet rich in fruits, vegetables, and lean meats, and try to keep your body healthy. That’s the most important thing we can do for risk reduction for multiple cancers, not just pancreatic.”

Originally published in July 2106 and updated.

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Jim Black

Jim Black has served as executive editor of Cleveland Clinic’s Men’s Health Advisor newsletter since 2005. He has written about prostate diseases, men’s health, cardiovascular disease, cancer, and a wide … Read More

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