Is Prostate Cancer Hereditary?

Anyone who's had a close relative diagnosed will wonder: Is prostate cancer hereditary? In fact, a combination of genetics and several other factors—some known, others undiscovered—can come into play.

is prostate cancer hereditary

Is prostate cancer hereditary? A number of factors—some known, some not yet discovered—can factor into the equation.

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For many types of cancer, having a family history of the disease places you at a greater risk of developing the cancer yourself. So, if you’re a man with a close relative who had prostate cancer, you might be bothered by a lingering question: Is prostate cancer hereditary?

No one knows for sure what causes prostate cancer, but researchers have identified several genetic factors linked to increased prostate cancer risk. And, recent research provides an estimate of how great the risk of prostate cancer is in men with a family history of the disease.

According to the American Cancer Society, your personal risk of prostate cancer doubles if your father or brother had the disease, and it’s even greater if several of your relatives had it, particularly if they were young when they were diagnosed.

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Is Prostate Cancer Hereditary? Research Addresses Genetics

A recent study has estimated how greatly your family history might influence your risk of prostate cancer. Researchers reviewed data on nearly 52,000 Swedish men with brothers and fathers who had prostate cancer. Compared with the general population, men with a brother who had prostate cancer were more than twice as likely to be diagnosed with prostate cancer and faced nearly twice the risk of developing an aggressive form by age 75.

And, the study found, men with both a father and brother who had prostate cancer faced more than a threefold increased risk of being diagnosed with prostate cancer and a nearly threefold risk of aggressive prostate cancer by age 75, compared with the general population.

The likelihood of developing aggressive prostate cancer was about as great in men whose fathers or brothers had lower-risk prostate cancer as those whose relatives had aggressive prostate cancer, the researchers reported (Journal of the National Cancer Institute, October 2016).

“We had expected that the risk of aggressive prostate cancer would be particularly lower in men with favorable cancer in the family, but that wasn’t the case,” study author Ola Bratt, a researcher at Lund University, in Sweden, said in a statement. “Men whose fathers or brothers had a favorable prostate cancer don’t usually think that increases their own risk of developing aggressive cancer. They might not even know that they have prostate cancer in the family.”

Understand Your Genetic Risks

So, is prostate cancer hereditary? The answer may lie in the dozens of genetic mutations, or variants, that have been associated with varying degrees of prostate cancer risk, as well as the additional suspect genes that are being researched. Having one of these genetic defects does not mean you will get prostate cancer, but it does increase the likelihood, which is probably why some families have a history of prostate cancer.

FOR FURTHER INFORMATION…

Is prostate cancer genetic? The National Cancer Institute offers a report called Genetics of Prostate Cancer. Click here to access that information.

For instance, if a woman in your family developed breast cancer caused by mutations in the BRCA1 and BRCA2 genes, you may face a greater risk of prostate cancer. Moreover, some evidence suggests that men with BRCA-related prostate cancers, especially those tied to BRCA2, are more likely to present with more advanced and aggressive disease, and they also might have worse survival outcomes after prostate cancer surgery.

In one study, researchers found that 8 percent of men with BRCA1 mutations and 5 percent with BRCA2 mutations were diagnosed with prostate cancer, rates higher than those in the general population (American Urological Association 2017 Annual Scientific Meeting).

Another analysis found that 71 percent of BRCA2 prostate cancer patients presented with higher-risk disease at the time of their diagnosis, had poorer survival rates, and were four times more likely than men without the genetic mutation to present with metastatic disease (American Urological Association 2016 Annual Scientific Meeting).

Further Prostate Cancer Risk Factors

Some evidence suggests that an inherited genetic condition, Lynch syndrome, which has been linked to a greater risk of colorectal cancer and several other malignancies, also may be associated with a higher risk of prostate cancer.

Keep in mind that these inherited genetic disorders account for a relatively small percentage of prostate cancers—about 5 to 10 percent, according to the American Cancer Society. Still, if you have a strong family history of prostate cancer or any of these genetic abnormalities, it’s especially important to talk to your doctor about your individual risk of the disease and your need for earlier and more intensive prostate cancer screening.

SOURCES & RESOURCES

Scientists continue to pursue answers to the question “Is prostate cancer hereditary?” but in the meantime, men can take lifestyle steps to reduce their risk. For advice, visit our post How to Avoid Prostate Cancer.

For information on prostate cancer risks, symptoms, and stages, please visit these posts:

The same recommendation applies if you’re African-American. Prostate cancer occurs more commonly in African-American men and less so in Asian-American and Hispanic men. Rates of fatal prostate cancer also are significantly higher among African-Americans.

In fact, the risk of preclinical prostate cancer among black men is 28 to 56 percent higher than that in the general population, and although black men are about as likely as men of other races to be diagnosed with prostate cancer, their risk of progression to metastatic disease at the time of diagnosis is 44 to 75 percent higher than that in the general population, according to a recent study.

“The findings suggest screening black men earlier than white men, and support further research into the benefit-harm tradeoffs of more aggressive screening policies for black men,” the researchers concluded (Cancer, June 15, 2017).

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