Alzheimer’s Update: Predicting Progression from Normal Cognition to Mild Cognitive Impairment

Identifying who might progress to developing clinical symptoms at five or more years from baseline could lead to earlier intervention

A growing body of evidence indicates that the underlying neuropathological mechanisms associated with Alzheimer’s disease (AD) begin 10 years or more before cognitive impairment manifests. In 1995 the BIOCARD study (Biomarkers of Cognitive Decline among Normal Individuals) was developed to identify people who could be participants in AD clinical trials, as well as to identify people […]


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