6 Milk Thistle Uses: Protect Your Liver, Treat Diabetes, and More

6 Milk Thistle Uses: Protect Your Liver, Treat Diabetes, and MoreThe more I delve into the world of natural health with the research I do daily, the more impressed I am with the remarkable medicinal properties of the countless herbs and plants available in the natural world. Although they often go unnoticed and underused in the shadow of pharmaceutical drugs, there seems to be a natural option for almost any condition under the sun. One of my latest favorites? Milk thistle.

Milk thistle uses range from keeping your liver healthy to treating diabetes. The main extract of milk thistle is called silymarin, which contains many flavonoids and active components.

Protect your liver

Probably one of the most well-known milk thistle uses is protecting the liver. Silymarin can help the liver to repair itself, stimulate protein synthesis, and more.[1] It has beneficial effects in treating chronic liver diseases including fatty liver disease, alcoholic liver disease, cirrhosis, and hepatitis. People supplementing with it show lower liver-related mortality and complications from liver diseases as well.[1,2,3] Milk thistle has been used as a traditional “liver tonic” for centuries and can help with liver detoxification. Milk thistle can protect the liver and the body against toxins including alcohol, drugs, and toxic mushrooms.[2,3]

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Treat diabetes

Milk thistle extracts contain potent antioxidant compounds, which are known to be beneficial in treating diabetes. Silymarin has been shown to reduce blood sugar, protect insulin producing β-cells in the pancreas, and help diabetes patients in a variety of other ways.[4] In one study, 200 mg three times a day significantly reduced fasting blood glucose in people with type 2 diabetes, and it also lowered total cholesterol, LDL cholesterol, and triglycerides in this group.[5] Similar results have been found in other studies.[6] Milk thistle also can help prevent complications of diabetes.

Keep your kidneys healthy

Recent research shows that milk thistle might be just as important for kidney health as it is for liver health.[7] One of the complications of diabetes is diabetic nephropathy, which is damage of the kidneys that can lead to end-stage kidney disease. Silymarin has been shown to help slow the progression of diabetic nephropathy through its antioxidant and anti-inflammatory qualities, among other mechanisms.[1,8,9] In one study, patients given 140 mg of silymarin for three months showed significantly better markers of nephropathy than those receiving placebo.[8]

Fight cancer

Although human studies are still lacking, laboratory studies show that silymarin has protective effects against cancer, especially in prostate, breast, and ovarian cancer cells.[7,10] This is likely due to the high antioxidant activity of the flavonoid silymarin.

Boost bone health

Milk thistle also has applications in osteoporosis treatment and prevention. It shows promising effects such as promoting bone building, improving bone healing, and preventing bone loss in laboratory studies.[11,12]

Neurodegeneration

Laboratory evidence also suggests that milk thistle may be used to protect the brain from neurodegeneration. In animal models, silymarin administration has protected against and improved symptoms of both Alzheimer’s and Parkinson’s disease. It is believed to help protect the brain because it is an antioxidant, interferes with the formation of amyloid plaques, and more.[13]

Taking milk thistle

Milk thistle is considered safe, even for children and pregnant or lactating women. As always, consult with your doctor before taking any new supplement. The recommended dose is 100 to 200 mg standardized extract (70-80% silymarin) taken twice daily with meals.[7]

Share your experience

Do you have experience with any of these milk thistle uses? Have you ever taken milk thistle extract as a supplement? Share your tips in the comments section below.


[1] J Renal Inj Prev. 2012 Jan 1;1(1):3-5.

[2] Integr Cancer Ther. 2007 Jun;6(2):146-57.

[3] J Vet Intern Med. 2013 Jan-Feb;27(1):10-6.

[4] Int J Mol Sci. 2014 Nov 21;15(11):21505-37.

[5] Phytother Res. 2006 Dec;20(12):1036-9.

[6] J Med Food. 2007 Sep;10(3):543-7.

[7] J Evid Based Complementary Altern Med. 2015 Feb 16.

[8] Am J Kidney Dis. 2012 Dec;60(6):896-903.

[9] Antioxid Redox Signal. 2011 Feb 1;14(3):353-66.

[10] Eur J Pharmacol. 2014 Nov 15;743:79-88.

[11] Curr Drug Targets. 2013 Dec;14(14):1659-66.

[12] Biomed Res Int. 2013;2013:919374.

[13] CNS Neurosci Ther. 2013 Nov;19(11):847-53.

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