Grape Seed Extract Benefits Blood Pressure and Cholesterol

Grape Seed Extract Benefits Blood Pressure and CholesterolSix thousand years ago, the Egyptians recognized the healing power of grapes although they didn’t fully understand why the fruit is so beneficial. Today, we now know how grape seed extract works to naturally lower blood pressure and cholesterol levels. Grape seed extract contains a high percentage of compounds called oligomeric proanthocyanidins (OPCs for short).  OPCs from grape seed extract are flavonoids that have been well-known for some time as potent antioxidants that promote blood vessel strength and optimal eye health. More recently, however, researchers have discovered two new roles for OPCs: lowering blood pressure and cholesterol.

Grape seed extract for high cholesterol

Oxidized LDL particles play a key role in the formation of arterial plaques and the development of atherosclerosis. Grape seed extract decreased oxidized LDL particles in addition to lowering total and LDL cholesterol in a recent randomized double-blind placebo-controlled study.[1] Fifty-two individuals with mildly high cholesterol  were divided into two groups that received either 200 mg/day of grape seed extract or placebo for 8 weeks. The grape seed extract significantly reduced total cholesterol by an average of 10.7 mg/dL, LDL cholesterol by an average of 9.7 mg/dL, and oxidized LDL by an average of 5.5 mg/dL. While triglyceride and very low-density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by the grape seed extract, the changes were not statistically significant. The study authors concluded that grape seed extract lowers the risk of atherosclerosis and cardiovascular disorders in people with mild cholesterol abnormalities.

Grape seed extract for high blood pressure

When taken as a supplement, grape seed extract has also been shown to significantly lower blood pressure, in some small studies. Two studies performed at the University of California Davis, one in people with metabolic syndrome and one in people with prehypertension, both found that grape seed extract lowers both systolic (the top number) and diastolic (the bottom number) blood pressure. In the first study, 300 mg per day of grape seed extract (MegaNatural BP by Polyphenolics—a patented extract) lowered both the systolic and diastolic blood pressures compared to placebo in subjects with metabolic syndrome.[2] Those in the grape seed extract group experienced average blood pressure reductions of 12 mmHg systolic and 8 mmHg diastolic while those in the placebo group saw no changes. The grape seed extract also decreased the oxidation of LDL particles, lowering the subjects’ risk of atherosclerosis. In the second study, 32 participants with prehypertension (systolic blood pressure of 120-139 mmHg or a diastolic blood pressure of 80-89 mmHg) were randomly assigned to receive grape seed extract (300 mg per day) or placebo for eight weeks.[3] Participants who took the grape seed extract reduced their systolic blood pressure by an average of 8 mmHg and diastolic blood pressure by 5 mmHg. The blood pressure of those in the placebo group did not change.

How to take grape seed extract as a supplement to lower high blood pressure and cholesterol

Grape seed extract is one of the most powerful antioxidants yet discovered. To take advantage of this natural compound for lowering blood pressure and cholesterol, look for grape (vitis vinifera) seed extract, standardized to contain at least 92%-95% polyphenols (including OPCs). Take 300 mg once a day or split the dose. Take the supplement for a full 12 weeks to get optimal results. Grape seed extract is not associated with side effects and there are no reported interactions between grape seed extract and any medications or supplements.

Tell us your favorite uses of grape seed extract in your family

Grape seed extract comes in liquid tincture form or in capsules, and it has literally dozens of uses around your home in addition to its blood pressure and cholesterol benefits. These include such uses as wrinkle and sagging skin improvement, a natural anti-histamine, and eye health restorer. Share in the comments section below how you use grape seed extract and what form (liquid or capsule) is your favorite.


[1] J Med Food. 2013 Mar;16(3):255-8.

[3] J Pharm Nutr Sci. 2012;2:155-159.

This post appeared n 2013 and has been updated.

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UHN Staff

University Health News is produced by the award-winning editors and authors of Belvoir Media Group’s Health & Wellness Division. Headquartered in Norwalk, Conn., with editorial offices in Florida, Cleveland, Pittsburgh, … Read More

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