Diabetic Shock and Diabetic Emergencies: Hypoglycemia vs. Hyperglycemia

What is diabetic shock? It's all about the highs and lows of your blood glucose level. Here, we discuss hypoglycemia vs. hyperglyclemia along with their complications.

diabetic shock

Confusion is a symptom of both hypoglycemia and hyperglycemia, which can lead to diabetic shock.

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Diabetic emergencies and diabetic shock can occur either when your blood glucose level becomes dangerously low (hypoglycemia) or when it becomes dangerously high (hyperglycemia). If you’re managing diabetes, it’s important to understand the difference—and how to react.

Hypoglycemia | Hyperglycemia

Here, we dig into both hypoglycemia and hyperglycemia, pinpointing the symptoms as well as the dangers of leaving them untreated.

What is Diabetic Shock?

A diabetic shock refers to the emergency that occurs when blood sugar either raises or lowers to dangerous levels for a diabetic. Diabetic shock caused by hypoglycemia can include seizures or unconsciousness. The diabetic emergencies that can occur because of hyperglycemia include:

  1. Diabetic ketoacidosis (DKA)
  2. Hyperosmolar hyperglycemic nonketotic syndrome (HHNS) (For information on how to avoid diabetic shock, please see our posts Dealing with Blood Sugar Levels and Normal Glucose Levels: Check Your Numbers.)

What Is Hypoglycemia?

Hypolgycemia, or low blood glucose, can occur in diabetics for a variety of reasons. It can be the result of simply having skipped a meal or having exercised too much for the amount of food you have consumed or medication you have taken. It can also be the consequence of insulin or insulin promoting medications.

Symptoms of Hypoglycemia

Symptoms low blood sugar levels can range from mild to severe:

Since the problem with hypoglycemia is low blood glucose, the treatment for mild symptoms is a dose (usually 15 to 20 grams) of glucose or simple carbohydrate, which is easily broken down into glucose. A 15- to 20-gram dose of glucose can come in the form of a variety of things, from glucose tablets to 4 ounces of juice to a tablespoon of honey.


Are you working to manage diabetes? Information is an important ally. See the following posts for help:

For hypoglycemia treatment, it’s imperative that you check your blood glucose level 15 minutes later to be certain you’re back within a safe range.

In more severe cases of hypoglycemia—true hypoglycemic emergencies such as when diabetic shock (including seizures or unconsciousness) occurs—injectable glucagon, a hormone that causes your liver to release glucose into the blood stream, is needed. Glucagon injection kits are available by prescription and can be injected into the arm, buttocks, or thigh.

Diabetics who have glucagon kits should be sure their friends, family, and coworkers are educated on glucagon administration in the event of an emergency. The glucagon typically takes effect within five to 15 minutes.

Oral glucose should not be administered if the patient is having seizures or unconscious as there is a significant risk of choking. If you experience hypoglycemia frequently or have experienced a diabetic shock situation, you must discuss this with your healthcare provider to determine if your insulin or medication regimen needs adjusting.

What Is Hyperglycemia?

Hyperglycemia in diabetics can occur for a variety of reasons, ranging from eating too much to the stress of an illness to insufficient glucose-lowering medications. The symptoms of mild hyperglycemia typically are increased thirst and frequent urination.

For mild hyperglycemia, exercise can often lower the blood glucose level. If you have developed a plan with your healthcare provider for treating certain elevated blood glucose levels with specific doses of glucose-lowering medications, this may be an option.

Persistent mildly elevated blood glucose levels often mean that you need to reevaluate your diet, exercise, and sometimes medication regimen with your healthcare provider.

There are two true diabetic emergencies characterized by hyperglycemia: diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic nonketotic syndrome (HHNS).

Diabetic ketoacidosis (DKA): This type of diabetic shock is often the first sign of diabetes. It can develop in individuals with type 1 or type 2 diabetes, but it is more common in type 1 diabetics.

DKA occurs when your body cannot use glucose as an energy source and instead begins to use fat as an energy source. The broken-down fat releases chemicals called ketones that build up in your blood and can make it dangerously acidic. The body will attempt to get rid of some of the ketones in the urine.

DKA can sometimes be the first sign of diabetes in a previously undiagnosed person, but in known diabetics it is often the result of missed insulin doses or some serious stress to the body (like infection, illness, or surgery). Early symptoms are increased thirst and urination. Early signs are elevated blood glucose and the presence of high levels of ketones in the urine.

Symptoms of Hyperglycemia

As DKA progresses, the diabetic shock symptoms become more severe:

  • Flushing
  • Fatigue
  • Nausea and vomiting
  • Abdominal pain
  • Dry skin
  • Fruity-smelling breath
  • Confusion
  • Difficulty breathing

If untreated, DKA can progress to coma and, ultimately, death. If you experience any of the symptoms of DKA and detect elevated blood glucose and urine ketone levels, you need to contact your healthcare provider immediately.

Treatment for DKA involves insulin therapy as well as careful intravenous fluid and electrolyte replacement.

Hyperosmolar hyperglycemic nonketotic syndrome (HHNS): Like DKA, HHNS can occur in either type 1 or type 2 diabetics, but unlike DKA, it tends to occur more often in type 2 diabetes.

With HHNS, blood glucose levels become dangerously high, often greater than 600mg/dl. With HHNS, there is enough residual beta cell function to prevent the body breaking down fat for energy; therefore, elevated urinary ketones aren’t commonly present.

The body tries to get rid of the excess glucose in the urine, but if you do not consume enough fluids or become dehydrated from an illness, the kidneys can no longer get rid of the excess glucose in the urine.

If you become dehydrated, the concentrations of sodium and other electrolytes build up in the blood along with the glucose and pull water from vital tissues and organs, including the brain. This hyperosmolar state produces a number of symptoms, including:

  • Increased thirst
  • Increased urination followed later by a darkening and reduction in urination
  • Dry mouth
  • Lethargy
  • Fever
  • Muscular weakness
  • Nausea
  • Confusion
  • Coma

Treatment of HHNS involves treatment of the precipitating cause (illness, infection, dehydration, poor diabetes management) insulin, and careful intravenous fluid and electrolyte replacement/management. HHNS is a very serious condition with a significant mortality rate, particularly in patients over the age of 65.

Originally published in 2016, this post is regularly updated. 

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Helen Boehm Johnson, MD

Helen Boehm Johnson, MD, is a medical writer who brings the experience of a residency-trained physician to her writing. She has written Massachusetts General Hospital’s Combating Memory Loss report (2019, 2020, … Read More

View all posts by Helen Boehm Johnson, MD

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