In the ongoing effort to find drugs that safely and effectively reduce cardiovascular events, there’s a new class of stars: PCSK9 inhibitors. These drugs are antibodies directed at the PCSK9 protein, which regulates LDL receptor recycling. Blocking the protein results in increasing the effective number of receptors, which leads to
Tag: pcsk9 inhibitors
You already know that keeping your cholesterol in check is important for heart health. High cholesterol is associated with clogged arteries and a greater chance of a heart attack. But you may be wondering: What exactly is a normal cholesterol level, and how do I get there? And you’re probably
Walking Enhances Creativity.
A recent study at Stanford University by Dr. Marily Oppezzo shows that creativity increases substantially when participants take a walk. Dr. Oppezzo gathered volunteer undergraduates to complete tests of creativity, such as finding alternative uses for common objects (such as a button). Then the students, who met in
Statins—taken by more than 25 million Americans to combat the high cholesterol levels that can harm cardiovascular health—are highly effective when it comes to lowering the risk for cardiovascular-related events and mortality. They also are low cost, and generally safe to take. However, for some people, statins come with side
Q. I have this strange thing going on with the fingers on my left hand. My ring and little fingers seem to be pulling toward the palm and curling. I don’t have osteoarthritis or rheumatoid arthritis. What could be happening?
A. You seem to be suffering from a condition called Dupuytren’s
Why Some Stents May Clog With Plaque
Drug-eluting stents (DES) were developed to prevent stents from clogging with plaque (in-stent restenosis), yet the problem occurs in about 16 percent of patients. Swiss researchers recently discovered these patients tend to have aggressive plaque growth throughout all their arteries. All patients in the
Two new cholesterol-lowering drugs may do more than provide alternatives for people who have serious side effects from statins. PCSK9 inhibitors may also help bring back specific targets in cholesterol treatment guidelines.
When the American College of Cardiology and the American Heart Association developed new cholesterol guidelines with the National Heart,
If the headlines about cholesterol have left you a little bewildered, it’s understandable.
First, the American Heart Association and American College of Cardiology changed long-standing guidelines for treating high LDL (“bad”) cholesterol to reduce the risk of cardiovascular disease (CVD) in 2013. They advised against continued use of specific LDL target
Shorter Course of Radiation Beneficial for Breast Cancer Patients
Among women with breast cancer who have had a tumor surgically removed, researchers have found that a shorter course of higher-dose radiation to one area of the breast yields similar results as a longer course of radiation to the entire breast. Data
Cholesterol-lowering statins are wonder drugs for reducing low-density lipoprotein (LDL, “bad”) cholesterol and lessening cardiovascular risk. Yet, a significant number of patients cannot tolerate the medications or fail to reach target LDL levels despite being on maximum-dose statin therapy.
Enter a new class of drugs—proprotein convertase subtilisin kexin type 9 (PCSK9)