8 Serotonin Deficiency Symptoms That You Can Identify Yourself

If you’re feeling pessimistic, sad, distrustful, unconfident, or ready to have a panic attack, you may have a serotonin deficiency.

serotonin deficiency

Adequate serotonin levels in the brain contribute to our feeling positive, happy, confident, and flexible. Low levels can lead to negative, worried, or irritable feelings.

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Serotonin is a powerful brain chemical that profoundly affects your mood, so knowing whether you’re deficient is a key first step to overcoming troubling mood and impulse control problems. Having one or more of the eight serotonin deficiency symptoms discussed here will be a strong clue that you may indeed be serotonin-deficient.

Serotonin is one of the so-called inhibitory neurotransmitters that serve to balance any excessive excitatory (stimulating) neurotransmitter (like dopamine) firing in the brain. With adequate serotonin levels in the brain and its proper functioning, you will be positive, happy, confident, flexible, and easygoing. With low levels of serotonin, you will begin to display serotonin deficiency symptoms by becoming negative, obsessive, worried, irritable, sleepless, or depressed. (See also “Serotonin Deficiency: A New Target for Mild Cognitive Impairment and Alzheimer’s.”)


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Serotonin Deficiency? Symptoms Tell the Story

Julia Ross, author of The Mood Cure, has an excellent mood type self-exam that can help you determine whether you have a serotonin or a dopamine (norepinephrine) deficiency. You may want to take the exam, but we’ll cover below some of the primary ways you can determine whether you’re having serotonin deficiency symptoms.

1. Is your depression negative in nature? That is, are your thoughts frequently pessimistic, gloomy, distrustful, and cynical?

2. Are you a woman? Women have depression more often than men and when they do, serotonin deficiency is more often a factor than in men. On the other hand, when men become depressed, they seem to more often have dopamine deficiencies where their depression is expressed as apathy or lack of interest or lack of the ability to focus.

This doesn’t mean that men can’t have serotonin deficiency and women can’t have dopamine deficiency—they can—but the general tendency is the other way around. A study published in September 2007 in the journal Biological Psychiatry showed that men and women react to serotonin deficiency in different ways.{1] The men became impulsive but not necessarily depressed. Women, on the other hand, experienced a marked drop in mood and became much more cautious, an emotional response commonly associated with depression.

The researchers conclude this may be why more women than men experience anxiety and mood disorders, while more men experience alcoholism, ADHD, and impulse control disorders. The message here is that women should especially be alert to the possibility of serotonin deficiency if they have clinical depression.

3. Do you crave sweets and starches? These are foods like breads and potato chips and any sugar-laden food. These foods temporarily raise serotonin levels and make you feel better so your body craves them. In the long run though they actually deplete serotonin levels and cause significant weight gain. Our blog post This is Your Brain on French Fries describes this harmful effect of processed carbs on the brain, but serotonin depletion is one of the main biochemical reasons behind the effect.

4. Do you have significant insomnia issues? Serotonin deficiency symptoms include waking up in the middle of the night and not being able to go back to sleep and having to sleep in many different positions in order to feel comfortable.

5. Do you have feelings of low self-esteem? That is, you’ve lost your confidence and sense of self worth. You easily become critical of yourself or feel guilty about something you’re doing or not doing.

6. Do you often feel worried, apprehensive or have panic attacks? False fear is a telltale sign of serotonin deficiency which can manifest itself as phobia, worry or even excessive shyness.

7. Do you sometimes exhibit aggressive or violent behavior even including thoughts of suicide? Studies show that serotonin deficiency in the brain is associated with an increased susceptibility to impulsive behavior, aggression, overeating, alcohol abuse, and violent suicide.

8. Have you had any of the following disorders: Fibromyalgia (unexplained muscle pain), TMJ (pain, tension, and grinding associated with your jaw), migraine headaches, irritable bowel syndrome, obesity, or asthma. Each of these have low serotonin levels implicated as an associated cause, and studies have shown that raising serotonin levels improves the condition severity.

Do these serotonin deficiency symptoms sound like you? If so, it is likely your body has become depleted of adequate levels of this important neurotransmitter – serotonin. Restoring serotonin levels in the brain and making sure it is working properly are critical but doable steps in recovering from any of these conditions. Fortunately, the body’s store of serotonin can be restored back to healthy levels through a natural health protocol involving the use of a specific amino acid supplement.

[1] Walderhaug, E. et al. Interactive Effects of Sex and 5-HTTLPR on Mood and Impulsivity During Tryptophan Depletion in Healthy People. Biological Psychiatry, September 15, 2007. 62:6.

This post was originally published in 2011 and has been updated.

  • Thank you so much for this information. Addressing my seratonin deficiency has made an enormous difference in my life.

  • Alicia C.

    I have all of these symptoms. I especially have problems with impulsivity, feelings of agression andaggitation. I am constantly nervous and have panic attacks. I also have been diagnosed with type one bipolar disorder.

  • Jack T.

    Would taking an SSRI like Prozac make the deficiency symptoms better or worse ?

  • Stephanie

    I have all these symptoms and have had depression for 32 yrs. after menopause I crave sweets and feel better once I have a mouthful, but it only lasts an hour or so. I have panic attacks that are so bad that I black out. I’m always tired and fall asleep at anytime. I really sick of being fat and overweight.

  • Nicole

    I recently had test done and Serotonin came back low. After reading about it I have all of this, it explains my insomnia, depression, and self-harming tendencies that we have never been able to fix. I am very hopeful that treating this will help, I had no idea it was even linked to TMJ!

  • Mandie K.

    Another way to naturally build your serotonin levels without having to buy amino acid supplements is through the nutritional program designed by Dr Kathleen DesMaisons (www.radiantrecovery.com). I have had immense success by following the steps of her program and changing my diet and raising my serotonin levels. It’s changed my life!

  • Linnea H.

    Please remove me from all related subscriptions

  • I cannot get to sleep..only thing that helps, some is lorezepam .

  • Michaela

    My daughter has all of the above. She has recently been diagnosed with an anxiety disorder and panic disorder. Her psychiatrist tells us that she has low serotonin levels and she is now on SSRI drugs. Can you tel me more about the body’s store of serotonin being restored back to healthy levels through a natural health protocol involving the use of a specific amino acid supplement.(as mentioned in your article) ?

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